Primary Hyperparathyroidism in Pregnancy: Literature Review of the Diagnosis and Management

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Jul 2

PMID 34209340

Citations 9

Authors

Dalal S Ali

Karel Dandurand

Aliya A Khan

Affiliations

Soon will be listed here.

Abstract

Background: Parathyroid disease is uncommon in pregnancy. During pregnancy, multiple changes occur in the calcium regulating hormones which may make the diagnosis of primary hyperparathyroidism more challenging. Close monitoring of serum calcium during pregnancy is necessary in order to optimize maternal and fetal outcomes. In this review, we will describe the diagnosis and management of primary hyperparathyroidism during pregnancy.

Methods: We searched MEDLINE, CINAHL, EMBASE and Google scholar bases from 1 January 1990 to 31 December 2020. Case reports, case series, book chapters and clinical guidelines were included in this review.

Conclusions: Medical management options for primary hyperparathyroidism during pregnancy are severely limited due to inadequate safety data with the various potential therapies available, and surgery is advised during the 2nd trimester of pregnancy in the presence of severe hypercalcemia (calcium adjusted for albumin greater than 3.0 mmol/L (12.0 mg/dL)). Hypercalcemia should be avoided during pregnancy in order to minimize maternal and fetal complications.

Citing Articles

Pregnancy Complicated by Primary Hyperparathyroidism-A Case Report on the Use of Cinacalcet.

Goncalves J, Freitas G, Souto S, Rodrigues T, Sa Couto P, Belo S Clin Case Rep. 2025; 13(3):e70305.

PMID: 40051898 PMC: 11882751. DOI: 10.1002/ccr3.70305.

Persistent challenges in the diagnosis of acute pancreatitis due to primary hyperparathyroidism during pregnancy.

Viet Luong T, Le L, Nguyen N, Nguyen Ngoc Dang H World J Gastroenterol. 2025; 31(7):100973.

PMID: 39991684 PMC: 11755251. DOI: 10.3748/wjg.v31.i7.100973.

A giant parathyroid cyst causing primary hyperparathyroidism in a pregnant woman: Case report and literature review.

Paz-Ibarra J, Concepcion-Zavaleta M, Coronado-Arroyo J, Quiroz-Aldave J, Pino-Godoy P, Diaz-Lazo H Obstet Med. 2024; :1753495X241249201.

PMID: 39553190 PMC: 11563524. DOI: 10.1177/1753495X241249201.

Primary hyperparathyroidism-induced acute pancreatitis in pregnancy: A systematic review with a diagnostic-treatment algorithm.

Augustin G, Lai Q, Cigrovski Berkovic M World J Gastroenterol. 2024; 30(32):3755-3765.

PMID: 39221064 PMC: 11362877. DOI: 10.3748/wjg.v30.i32.3755.

Use of Cinacalcet for the Management of Primary Hyperparathyroidism in Pregnancy.

Foster E, Maalouf N JCEM Case Rep. 2024; 2(7):luae117.

PMID: 39011404 PMC: 11247167. DOI: 10.1210/jcemcr/luae117.

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