Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea

Overview

Journal Nutrients

Date 2021 Jul 2

PMID 34204751

Citations 7

Authors

Kouya Hattori

Masahiro Akiyama

Natsumi Seki

Kyosuke Yakabe

Koji Hase

Yun-Gi Kim

Affiliations

Soon will be listed here.

Abstract

While poorly-absorbed sugar alcohols such as sorbitol are widely used as sweeteners, they may induce diarrhea in some individuals. However, the factors which determine an individual's susceptibility to sugar alcohol-induced diarrhea remain unknown. Here, we show that specific gut bacteria are involved in the suppression of sorbitol-induced diarrhea. Based on 16S rDNA analysis, the abundance of Enterobacteriaceae bacteria increased in response to sorbitol consumption. We found that of the family Enterobacteriaceae degraded sorbitol and suppressed sorbitol-induced diarrhea. Finally, we showed that the metabolism of sorbitol by the sugar phosphotransferase system helped suppress sorbitol-induced diarrhea. Therefore, gut microbiota prevented sugar alcohol-induced diarrhea by degrading sorbitol in the gut. The identification of the gut bacteria which respond to and degrade sugar alcohols in the intestine has implications for microbiome science, processed food science, and public health.

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References

Islam M, Sakaguchi E . Sorbitol-based osmotic diarrhea: possible causes and mechanism of prevention investigated in rats. World J Gastroenterol. 2006; 12(47):7635-41. PMC: 4088045. DOI: 10.3748/wjg.v12.i47.7635. View

Lenhart A, Chey W . A Systematic Review of the Effects of Polyols on Gastrointestinal Health and Irritable Bowel Syndrome. Adv Nutr. 2017; 8(4):587-596. PMC: 5508768. DOI: 10.3945/an.117.015560. View

Tsuda A, Suda W, Morita H, Takanashi K, Takagi A, Koga Y . Influence of Proton-Pump Inhibitors on the Luminal Microbiota in the Gastrointestinal Tract. Clin Transl Gastroenterol. 2015; 6:e89. PMC: 4816248. DOI: 10.1038/ctg.2015.20. View

Ruiz-Ojeda F, Plaza-Diaz J, Saez-Lara M, Gil A . Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials. Adv Nutr. 2019; 10(suppl_1):S31-S48. PMC: 6363527. DOI: 10.1093/advances/nmy037. View

Bolger A, Lohse M, Usadel B . Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014; 30(15):2114-20. PMC: 4103590. DOI: 10.1093/bioinformatics/btu170. View

Westermayer S, Fritz G, Gutierrez J, Megerle J, Weissl M, Schnetz K . Single-cell characterization of metabolic switching in the sugar phosphotransferase system of Escherichia coli. Mol Microbiol. 2016; 100(3):472-85. DOI: 10.1111/mmi.13329. View

Costea P, Hildebrand F, Arumugam M, Backhed F, Blaser M, Bushman F . Enterotypes in the landscape of gut microbial community composition. Nat Microbiol. 2017; 3(1):8-16. PMC: 5832044. DOI: 10.1038/s41564-017-0072-8. View

Mattes R, Popkin B . Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr. 2008; 89(1):1-14. PMC: 2650084. DOI: 10.3945/ajcn.2008.26792. View

Sanders M, Merenstein D, Reid G, Gibson G, Rastall R . Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol. 2019; 16(10):605-616. DOI: 10.1038/s41575-019-0173-3. View

10.

Tan J, McKenzie C, Vuillermin P, Goverse G, Vinuesa C, Mebius R . Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways. Cell Rep. 2016; 15(12):2809-24. DOI: 10.1016/j.celrep.2016.05.047. View

11.

Ye R, Wong S . Transcriptional regulation of the Bacillus subtilis glucitol dehydrogenase gene. J Bacteriol. 1994; 176(11):3314-20. PMC: 205502. DOI: 10.1128/jb.176.11.3314-3320.1994. View

12.

Yamada M, Saier Jr M . Positive and negative regulators for glucitol (gut) operon expression in Escherichia coli. J Mol Biol. 1988; 203(3):569-83. DOI: 10.1016/0022-2836(88)90193-3. View

13.

Koh A, De Vadder F, Kovatcheva-Datchary P, Backhed F . From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Cell. 2016; 165(6):1332-1345. DOI: 10.1016/j.cell.2016.05.041. View

14.

Marley J, Lu M, Bracken C . A method for efficient isotopic labeling of recombinant proteins. J Biomol NMR. 2001; 20(1):71-5. DOI: 10.1023/a:1011254402785. View

15.

Velazquez E, Nguyen H, Heasley K, Saechao C, Gil L, Rogers A . Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection. Nat Microbiol. 2019; 4(6):1057-1064. PMC: 6533147. DOI: 10.1038/s41564-019-0407-8. View

16.

Zhang Y, Li S, Gan R, Zhou T, Xu D, Li H . Impacts of gut bacteria on human health and diseases. Int J Mol Sci. 2015; 16(4):7493-519. PMC: 4425030. DOI: 10.3390/ijms16047493. View

17.

Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T . The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun. 2013; 4:1829. PMC: 3674247. DOI: 10.1038/ncomms2852. View

18.

ROBERTSON J . Computer applications in nuclear medicine. J Chronic Dis. 1966; 19(4):443-59. DOI: 10.1016/0021-9681(66)90119-6. View

19.

Million M, Lagier J, Yahav D, Paul M . Gut bacterial microbiota and obesity. Clin Microbiol Infect. 2013; 19(4):305-13. DOI: 10.1111/1469-0691.12172. View

20.

Ishizuka A, Tomizuka K, Aoki R, Nishijima T, Saito Y, Inoue R . Effects of administration of Bifidobacterium animalis subsp. lactis GCL2505 on defecation frequency and bifidobacterial microbiota composition in humans. J Biosci Bioeng. 2012; 113(5):587-91. DOI: 10.1016/j.jbiosc.2011.12.016. View