Hyperactivated RAGE in Comorbidities As a Risk Factor for Severe COVID-19-The Role of RAGE-RAS Crosstalk

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2021 Jul 2

PMID 34204735

Citations 18

Authors

Sara Chiappalupi

Laura Salvadori

Rosario Donato

Francesca Riuzzi

Guglielmo Sorci

Affiliations

Soon will be listed here.

Abstract

The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has been reported to sustain inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential to the deleterious effects of the renin-angiotensin system (RAS), which participates in infection and multiorgan injury in COVID-19 patients. Thus, RAGE might be a major player in severe COVID-19, and appears to be a useful therapeutic molecular target in infections by SARS-CoV-2. The role of RAGE gene polymorphisms in predisposing patients to severe COVID-19 is discussed.&nbsp.

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