PPARγ Agonists: Emergent Therapy in Endometriosis

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2021 Jul 2

PMID 34204039

Citations 8

Authors

Alexandre Vallee

Jean-Noel Vallee

Alain Le Blanche

Yves Lecarpentier

Affiliations

Soon will be listed here.

Abstract

Endometriosis is one of the major gynecological diseases of reproductive-age women. This disease is characterized by the presence of glands and stroma outside the uterine cavity. Several studies have shown the major role of inflammation, angiogenesis, adhesion and invasion, and apoptosis in endometriotic lesions. Nevertheless, the mechanisms underlying endometriotic mechanisms still remain unclear and therapies are not currently efficient. The introduction of new agents can be effective by improving the condition of patients. PPARγ ligands can directly modulate these pathways in endometriosis. However, data in humans remain low. Thus, the purpose of this review is to summarize the potential actions of PPARγ agonists in endometriosis by acting on inflammation, angiogenesis, invasion, adhesion, and apoptosis.

Citing Articles

Oxidative Stress and the Nrf2/PPARγ Axis in the Endometrium: Insights into Female Fertility.

Artimovic P, Badovska Z, Toporcerova S, Spakova I, Smolko L, Sabolova G Cells. 2024; 13(13.

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Transgenic mice applications in the study of endometriosis pathogenesis.

Zhao Y, Wang Y, Gu P, Tuo L, Wang L, Jiang S Front Cell Dev Biol. 2024; 12:1376414.

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Tanshinone ⅡA participates in the treatment of endometriosis by regulating adhesion, invasion, angiogenesis and inhibition of PI3K/Akt/mTOR signaling pathway.

Zhang X, Li S, Chen Z, Liang W, Pei S, Gou F Mol Med Rep. 2023; 28(5).

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Identification and validation of risk score model based on gene set activity as a diagnostic biomarker for endometriosis.

Zhang Y, Wu L, Wen X, Lv X Heliyon. 2023; 9(7):e18277.

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