Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in Diabetic Mice

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jul 2

PMID 34203569

Citations 2

Authors

Akio Watanabe

Marilia Oliveira de Almeida

Yusuke Deguchi

Ryuzo Kozuka

Caroline Arruda

Andresa Aparecida Berreta

Jairo Kenupp Bastos

Je-Tae Woo

Takayuki Yonezawa

Affiliations

Soon will be listed here.

Abstract

Propolis is a honeybee product with various biological activities, including antidiabetic effects. We previously reported that artepillin C, a prenylated cinnamic acid derivative isolated from Brazilian green propolis, acts as a peroxisome proliferator-activated receptor γ (PPARγ) ligand and promotes adipocyte differentiation. In this study, we examined the effect of baccharin, another major component of Brazilian green propolis, on adipocyte differentiation. The treatment of mouse 3T3-L1 preadipocytes with baccharin resulted in increased lipid accumulation, cellular triglyceride levels, glycerol-3-phosphate dehydrogenase activity, and glucose uptake. The mRNA expression levels of PPARγ and its target genes were also increased by baccharin treatment. Furthermore, baccharin enhanced PPARγ-dependent luciferase activity, suggesting that baccharin promotes adipocyte differentiation via PPARγ activation. In diabetic mice, intraperitoneal administration of 50 mg/kg baccharin significantly improved blood glucose levels. Our results suggest that baccharin has a hypoglycemic effect on glucose metabolic disorders, such as type 2 diabetes mellitus.

Citing Articles

Propolis and its constituents against cardiovascular risk factors including obesity, hypertension, atherosclerosis, diabetes, and dyslipidemia: A comprehensive review.

Khoshandam A, Hedayatian A, Mollazadeh A, Razavi B, Hosseinzadeh H Iran J Basic Med Sci. 2023; 26(8):853-871.

PMID: 37427329 PMC: 10329244. DOI: 10.22038/IJBMS.2023.67793.14835.

The Effect of Phytochemicals and Food Bioactive Compounds on Diabetes.

Yagasaki K, Muller C Int J Mol Sci. 2022; 23(14).

PMID: 35887112 PMC: 9324179. DOI: 10.3390/ijms23147765.

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