Polyunsaturated Fatty Acids Mediated Regulation of Membrane Biochemistry and Tumor Cell Membrane Integrity

Overview

Journal Membranes (Basel)

Date 2021 Jul 2

PMID 34203433

Citations 21

Authors

Souvik Mukerjee

Abdulaziz S Saeedan

Mohd Nazam Ansari

Manjari Singh

Affiliations

Soon will be listed here.

Abstract

Particular dramatic macromolecule proteins are responsible for various cellular events in our body system. Lipids have recently recognized a lot more attention of scientists for understanding the relationship between lipid and cellular function and human health However, a biological membrane is formed with a lipid bilayer, which is called a P-L-P design. Our body system is balanced through various communicative signaling pathways derived from biological membrane proteins and lipids. In the case of any fatal disease such as cancer, the biological membrane compositions are altered. To repair the biological membrane composition and prevent cancer, dietary fatty acids, such as omega-3 polyunsaturated fatty acids, are essential in human health but are not directly synthesized in our body system. In this review, we will discuss the alteration of the biological membrane composition in breast cancer. We will highlight the role of dietary fatty acids in altering cellular composition in the P-L-P bilayer. We will also address the importance of omega-3 polyunsaturated fatty acids to regulate the membrane fluidity of cancer cells.

Citing Articles

Omega-3 fatty acids: molecular weapons against chemoresistance in breast cancer.

Marchio V, Augimeri G, Morelli C, Vivacqua A, Giordano C, Catalano S Cell Mol Biol Lett. 2025; 30(1):11.

PMID: 39863855 PMC: 11762563. DOI: 10.1186/s11658-025-00694-x.

Parkia biglobosa Jacq. (Locust Bean) leaves and seeds extracts attenuates diabetic-linked cognitive dysfunction in streptozotocin-induced male wistar rats.

Ajiboye O, Ogunwenmo K, Adewumi A, Mohanye C Metab Brain Dis. 2024; 40(1):76.

PMID: 39714608 DOI: 10.1007/s11011-024-01514-5.

Evaluating Red Blood Cells' Membrane Fluidity in Diabetes: Insights, Mechanisms, and Future Aspects.

Pitocco D, Hatem D, Riente A, Giulio M, Rizzi A, Abeltino A Diabetes Metab Res Rev. 2024; 41(1):e70011.

PMID: 39627974 PMC: 11615262. DOI: 10.1002/dmrr.70011.

Microencapsulation and characterization of pomegranate seed oil using gum Arabic and maltodextrin blends for functional food applications.

Mangope K, Kaseke T, Fawole O Food Sci Nutr. 2024; 12(11):9252-9267.

PMID: 39620037 PMC: 11606825. DOI: 10.1002/fsn3.4493.

Prospecting Pharmacologically Active Biocompounds from the Amazon Rainforest: In Vitro Approaches, Mechanisms of Action Based on Chemical Structure, and Perspectives on Human Therapeutic Use.

de Almada-Vilhena A, Dos Santos O, Machado M, Nagamachi C, Pieczarka J Pharmaceuticals (Basel). 2024; 17(11).

PMID: 39598361 PMC: 11597570. DOI: 10.3390/ph17111449.

References

Bougnoux P, Hajjaji N, Ferrasson M, Giraudeau B, Couet C, Le Floch O . Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial. Br J Cancer. 2009; 101(12):1978-85. PMC: 2779856. DOI: 10.1038/sj.bjc.6605441. View

Bergareche A, Bednarz M, Sanchez E, Krebs C, Ruiz-Martinez J, de la Riva P . SCN4A pore mutation pathogenetically contributes to autosomal dominant essential tremor and may increase susceptibility to epilepsy. Hum Mol Genet. 2015; 24(24):7111-20. PMC: 4654061. DOI: 10.1093/hmg/ddv410. View

Mollinedo F, Gajate C, Martin-Santamaria S, Gago F . ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Curr Med Chem. 2004; 11(24):3163-84. DOI: 10.2174/0929867043363703. View

Amara S, Ivy M, Myles E, Tiriveedhi V . Sodium channel γENaC mediates IL-17 synergized high salt induced inflammatory stress in breast cancer cells. Cell Immunol. 2016; 302:1-10. PMC: 4792675. DOI: 10.1016/j.cellimm.2015.12.007. View

Bohdanowicz M, Grinstein S . Role of phospholipids in endocytosis, phagocytosis, and macropinocytosis. Physiol Rev. 2013; 93(1):69-106. DOI: 10.1152/physrev.00002.2012. View

Cerchietti L, Navigante A, Castro M . Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer. Nutr Cancer. 2007; 59(1):14-20. DOI: 10.1080/01635580701365068. View

Beyaz S, Mana M, Roper J, Kedrin D, Saadatpour A, Hong S . High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016; 531(7592):53-8. PMC: 4846772. DOI: 10.1038/nature17173. View

Agwa A, Peigneur S, Chow C, Lawrence N, Craik D, Tytgat J . Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018; 293(23):9041-9052. PMC: 5995520. DOI: 10.1074/jbc.RA118.002553. View

Altenburg J, Bieberich A, Terry C, Harvey K, Vanhorn J, Xu Z . A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. BMC Cancer. 2011; 11:149. PMC: 3111403. DOI: 10.1186/1471-2407-11-149. View

10.

Fabian C, Kimler B, Phillips T, Nydegger J, Kreutzjans A, Carlson S . Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women. Cancer Prev Res (Phila). 2015; 8(10):922-31. PMC: 4596784. DOI: 10.1158/1940-6207.CAPR-14-0336. View

11.

Wen Z, Su Y, Lai P, Zhang Y, Xu Y, Zhao A . Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis. Oncogene. 2012; 32(2):160-70. DOI: 10.1038/onc.2012.47. View

12.

Veldman R, Zerp S, van Blitterswijk W, Verheij M . N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx. Br J Cancer. 2004; 90(4):917-25. PMC: 2410169. DOI: 10.1038/sj.bjc.6601581. View

13.

Weylandt K, Chiu C, Gomolka B, Waechter S, Wiedenmann B . Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. Prostaglandins Other Lipid Mediat. 2012; 97(3-4):73-82. DOI: 10.1016/j.prostaglandins.2012.01.005. View

14.

Fan Y, Zhan Y, Aukema H, Davidson L, Zhou L, Callaway E . Proapoptotic effects of dietary (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice. J Nutr. 2009; 139(7):1328-32. PMC: 2696987. DOI: 10.3945/jn.109.106203. View

15.

Baptista-Hon D, Robertson F, Robertson G, Owen S, Rogers G, Lydon E . Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function. Br J Anaesth. 2014; 113 Suppl 1:i39-i48. DOI: 10.1093/bja/aeu104. View

16.

Yadav R, Singh M, Roy S, Ansari M, Saeedan A, Kaithwas G . Modulation of oxidative stress response by flaxseed oil: Role of lipid peroxidation and underlying mechanisms. Prostaglandins Other Lipid Mediat. 2018; 135:21-26. DOI: 10.1016/j.prostaglandins.2018.02.003. View

17.

Fearon K, Barber M, Moses A, Ahmedzai S, Taylor G, Tisdale M . Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia. J Clin Oncol. 2006; 24(21):3401-7. DOI: 10.1200/JCO.2005.04.5724. View

18.

Bloch K . Sterol structure and membrane function. CRC Crit Rev Biochem. 1983; 14(1):47-92. DOI: 10.3109/10409238309102790. View

19.

Rani A, Roy S, Singh M, Devi U, Yadav R, Gautam S . α-Chymotrypsin regulates free fatty acids and UCHL-1 to ameliorate N-methyl nitrosourea induced mammary gland carcinoma in albino wistar rats. Inflammopharmacology. 2016; 24(5):277-286. DOI: 10.1007/s10787-016-0280-5. View

20.

Fulda S, Galluzzi L, Kroemer G . Targeting mitochondria for cancer therapy. Nat Rev Drug Discov. 2010; 9(6):447-64. DOI: 10.1038/nrd3137. View