Bioengineering Progress in Lung Assist Devices

Overview

Journal Bioengineering (Basel)

Date 2021 Jul 2

PMID 34203316

Citations 3

Authors

Ahad Syed

Sarah Kerdi

Adnan Qamar

Affiliations

Soon will be listed here.

Abstract

Artificial lung technology is advancing at a startling rate raising hopes that it would better serve the needs of those requiring respiratory support. Whether to assist the healing of an injured lung, support patients to lung transplantation, or to entirely replace native lung function, safe and effective artificial lungs are sought. After 200 years of bioengineering progress, artificial lungs are closer than ever before to meet this demand which has risen exponentially due to the COVID-19 crisis. In this review, the critical advances in the historical development of artificial lungs are detailed. The current state of affairs regarding extracorporeal membrane oxygenation, intravascular lung assists, pump-less extracorporeal lung assists, total artificial lungs, and microfluidic oxygenators are outlined.

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References

MacLaren G, Combes A, Bartlett R . Contemporary extracorporeal membrane oxygenation for adult respiratory failure: life support in the new era. Intensive Care Med. 2011; 38(2):210-20. DOI: 10.1007/s00134-011-2439-2. View

Scipione C, Schewe R, Koch K, Shaffer A, Iyengar A, Cook K . Use of a low-resistance compliant thoracic artificial lung in the pulmonary artery to pulmonary artery configuration. J Thorac Cardiovasc Surg. 2013; 145(6):1660-6. PMC: 3653992. DOI: 10.1016/j.jtcvs.2013.01.020. View

Moen O, Fosse E, Dregelid E, Brockmeier V, Andersson C, Hogasen K . Centrifugal pump and heparin coating improves cardiopulmonary bypass biocompatibility. Ann Thorac Surg. 1996; 62(4):1134-40. DOI: 10.1016/0003-4975(96)00492-4. View

Kolobow T, Gattinoni L, Tomlinson T, Pierce J . Control of breathing using an extracorporeal membrane lung. Anesthesiology. 1977; 46(2):138-41. DOI: 10.1097/00000542-197702000-00012. View

Kumar Mahto S, Tenenbaum-Katan J, Sznitman J . Respiratory physiology on a chip. Scientifica (Cairo). 2013; 2012:364054. PMC: 3820443. DOI: 10.6064/2012/364054. View

Goodin M, Thor E, Haworth W . Use of computational fluid dynamics in the design of the Avecor Affinity oxygenator. Perfusion. 1994; 9(3):217-22. DOI: 10.1177/026765919400900310. View

Murphy W, Trudell L, Friedman L, Kakvan M, Richardson P, Karlson K . Laboratory and clinical experience with a microporous membrane oxygenator. Trans Am Soc Artif Intern Organs. 1974; 20A:278-85. View

Kniazeva T, Hsiao J, Charest J, Borenstein J . A microfluidic respiratory assist device with high gas permeance for artificial lung applications. Biomed Microdevices. 2010; 13(2):315-23. DOI: 10.1007/s10544-010-9495-1. View

Montoya J, Shanley C, Merz S, Bartlett R . Plasma leakage through microporous membranes. Role of phospholipids. ASAIO J. 1992; 38(3):M399-405. DOI: 10.1097/00002480-199207000-00064. View

10.

Mihelc K, Frankowski B, Lieber S, Moore N, Hattler B, Federspiel W . Evaluation of a respiratory assist catheter that uses an impeller within a hollow fiber membrane bundle. ASAIO J. 2009; 55(6):569-74. DOI: 10.1097/MAT.0b013e3181bc2655. View

11.

Campbell T . Changing criteria for the artificial lung. Historic controls on the technology of ECMO. ASAIO J. 1994; 40(2):109-20. View

12.

Khoshbin E, Westrope C, Pooboni S, Machin D, Killer H, Peek G . Performance of polymethyl pentene oxygenators for neonatal extracorporeal membrane oxygenation: a comparison with silicone membrane oxygenators. Perfusion. 2005; 20(3):129-34. DOI: 10.1191/0267659105pf797oa. View

13.

Kolobow T, Bowman R . Construction and evaluation of an alveolar membrane artificial heart-lung. Trans Am Soc Artif Intern Organs. 1963; 9:238-43. View

14.

Tsuji T, Suma K, Tanishita K, Fukazawa H, Kanno M, Hasegawa H . Development and clinical evaluation of hollow fiber membrane oxygenator. Trans Am Soc Artif Intern Organs. 1981; 27:280-4. View

15.

HEIMBECKER R . Letter: The membrane lung--a quiet revolution. Am J Cardiol. 1976; 37(7):1117-8. DOI: 10.1016/0002-9149(76)90446-x. View

16.

BERNE R, Cross F, Hirose Y, Jones R, KAY E . Evaluation of a rotating disc type reservoir-oxygenator. Proc Soc Exp Biol Med. 1956; 93(2):210-4. DOI: 10.3181/00379727-93-22710. View

17.

Lu S, Lin H, Kuo H, Wu C, Wu W, Chen C . Design and Study of a Portable High-frequency Ventilator for Clinical Applications. Annu Int Conf IEEE Eng Med Biol Soc. 2020; 2019:2353-2356. DOI: 10.1109/EMBC.2019.8857805. View

18.

Spratt E, MELROSE D, Bellhouse B, Badolato A, Thompson R . Evaluation of a membrane oxygenator for clinical cardiopulmonary bypass. Trans Am Soc Artif Intern Organs. 1981; 27:285-8. View

19.

Khoshbin E, Roberts N, Harvey C, Machin D, Killer H, Peek G . Poly-methyl pentene oxygenators have improved gas exchange capability and reduced transfusion requirements in adult extracorporeal membrane oxygenation. ASAIO J. 2005; 51(3):281-7. DOI: 10.1097/01.mat.0000159741.33681.f1. View

20.

Eash H, Frankowski B, Hattler B, Federspiel W . Evaluation of local gas exchange in a pulsating respiratory support catheter. ASAIO J. 2005; 51(2):152-7. PMC: 2002489. DOI: 10.1097/01.mat.0000153648.11692.d0. View