Ketogenic Diet Decreases Alcohol Intake in Adult Male Mice

Overview

Journal Nutrients

Date 2021 Jul 2

PMID 34202492

Citations 12

Authors

Maria Del Carmen Blanco-Gandia

Francisco Rodenas-Gonzalez

Maria Pascual

Marina Daiana Reguilon

Consuelo Guerri

Jose Minarro

Marta Rodriguez-Arias

Affiliations

Soon will be listed here.

Abstract

The classic ketogenic diet is a diet high in fat, low in carbohydrates, and well-adjusted proteins. The reduction in glucose levels induces changes in the body's metabolism, since the main energy source happens to be ketone bodies. Recent studies have suggested that nutritional interventions may modulate drug addiction. The present work aimed to study the potential effects of a classic ketogenic diet in modulating alcohol consumption and its rewarding effects. Two groups of adult male mice were employed in this study, one exposed to a standard diet (SD, = 15) and the other to a ketogenic diet (KD, = 16). When a ketotic state was stable for 7 days, animals were exposed to the oral self-administration paradigm to evaluate the reinforcing and motivating effects of ethanol. Rt-PCR analyses were performed evaluating dopamine, adenosine, CB1, and Oprm gene expression. Our results showed that animals in a ketotic state displayed an overall decrease in ethanol consumption without changes in their motivation to drink. Gene expression analyses point to several alterations in the dopamine, adenosine, and cannabinoid systems. Our results suggest that nutritional interventions may be a useful complementary tool in treating alcohol-use disorders.

Citing Articles

Effects of Ketogenic Diet on Increased Ethanol Consumption Induced by Social Stress in Female Mice.

Torres-Rubio L, Reguilon M, Mellado S, Pascual M, Rodriguez-Arias M Nutrients. 2024; 16(17).

PMID: 39275131 PMC: 11397041. DOI: 10.3390/nu16172814.

A Complex Interplay between Nutrition and Alcohol use Disorder: Implications for Breaking the Vicious Cycle.

White B, Sirohi S Curr Pharm Des. 2024; 30(23):1822-1837.

PMID: 38797900 DOI: 10.2174/0113816128292367240510111746.

Nutritional ketosis as treatment for alcohol withdrawal symptoms in female C57BL/6J mice.

Tonetto S, Weikop P, Thomsen M Sci Rep. 2024; 14(1):5092.

PMID: 38429369 PMC: 10907582. DOI: 10.1038/s41598-024-55310-3.

Ketogenic diet reduces a neurobiological craving signature in inpatients with alcohol use disorder.

Wiers C, Manza P, Wang G, Volkow N Front Nutr. 2024; 11:1254341.

PMID: 38410637 PMC: 10895037. DOI: 10.3389/fnut.2024.1254341.

Ketone Supplementation Dampens Subjective and Objective Responses to Alcohol: Evidence From a Preclinical Rat Study and a Randomized, Cross-Over Trial in Healthy Volunteers.

Li X, Shi Z, Todaro D, Pond T, Byanyima J, Vesslee S Int J Neuropsychopharmacol. 2024; 27(2).

PMID: 38315678 PMC: 10901540. DOI: 10.1093/ijnp/pyae009.

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