Low Vitamin D Level Is Associated with Acute Deep Venous Thrombosis in Patients with Traumatic Brain Injury

Overview

Journal Brain Sci

Publisher MDPI

Date 2021 Jul 2

PMID 34202164

Citations 3

Authors

Matthew Moore

Yelena Goldin

Harsh Patel

Brian D Greenwald

Affiliations

Soon will be listed here.

Abstract

Vitamin D and its association with venous thromboembolism (VTE) have been studied in common rehabilitation populations, such as spinal cord injury and ischemic stroke groups. This study explores the relationship between vitamin D levels and acute deep venous thrombosis (DVT) in the traumatic brain injury (TBI) population. This is a retrospective cohort study that analyzes the relationship between vitamin D levels and the prevalence of DVT during acute inpatient rehabilitation. In this population, 62% (117/190) of patients had low vitamin D levels upon admission to acute rehabilitation. Furthermore, 21% (24/117) of patients in the low vitamin D group had acute DVT during admission to acute rehabilitation. In contrast, only 8% (6/73) of patients in the normal vitamin D group had acute DVT during admission to acute rehabilitation. Fisher's exact tests revealed significant differences between individuals with low and normal vitamin D levels ( = 0.025). In conclusion, a vitamin D level below 30 ng/mL was associated with increased probability of the occurrence of acute DVT in individuals with moderate-severe TBI.

Citing Articles

Recent Updates and Advances in the Association Between Vitamin D Deficiency and Risk of Thrombotic Disease.

Ojaroodi A, Jafarnezhad F, Eskandari Z, Keramat S, Stanek A Nutrients. 2025; 17(1.

PMID: 39796525 PMC: 11722561. DOI: 10.3390/nu17010090.

Is Circulating Vitamin D Status Associated with the Risk of Venous Thromboembolism? A Meta-Analysis of Observational Studies.

Hung K, Yang S, Chang C, Wang L, Lin Y, Yu C Nutrients. 2023; 15(5).

PMID: 36904113 PMC: 10005254. DOI: 10.3390/nu15051113.

Impact of vitamin D on the prognosis after spinal cord injury: A systematic review.

Wang L, Gan J, Wu J, Zhou Y, Lei D Front Nutr. 2023; 10:920998.

PMID: 36866055 PMC: 9973556. DOI: 10.3389/fnut.2023.920998.

Vitamin D Protects against Traumatic Brain Injury via Modulating TLR4/MyD88/NF-B Pathway-Mediated Microglial Polarization and Neuroinflammation.

Jiang H, Yang X, Wang Y, Zhou C Biomed Res Int. 2022; 2022:3363036.

PMID: 35872863 PMC: 9307360. DOI: 10.1155/2022/3363036.

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