As a Dynamic Vehicle for the Dissemination of Antimicrobial-Resistance Determinants: Review and In Silico Analysis

Overview

Journal Microorganisms

Specialty Microbiology

Date 2021 Jul 2

PMID 34202117

Citations 9

Authors

Philip Kartalidis

Anargyros Skoulakis

Katerina Tsilipounidaki

Zoi Florou

Efthymia Petinaki

George C Fthenakis

Affiliations

Soon will be listed here.

Abstract

The present paper is divided into two parts. The first part focuses on the role of in the accumulation of genes associated with antimicrobial resistance and then the transmission of them to other pathogenic bacteria occupying the same human intestinal niche. The second part describes an in silico analysis of the genomes of available in GenBank, with regard to the presence of mobile genetic elements and antimicrobial resistance genes. The diversity of the genome is discussed, and the current status of resistance of the organisms to various antimicrobial agents is reviewed. The role of transposons associated with antimicrobial resistance is appraised; the importance of plasmids associated with antimicrobial resistance is discussed, and the significance of bacteriophages as a potential shuttle for antimicrobial resistance genes is presented. In the in silico study, 1101 genomes were found to harbor mobile genetic elements; Tn, Tn, CTn and Tn, Tn and IS were the ones more frequently identified. The genes most commonly harbored therein were: , , , , and . Tn was likely associated with resistance to erythromycin, Tn and CTn with resistance to the β-lactams and vancomycin, IS with resistance to aminoglycoside and Tn to vancomycin.

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