New Insights into Non-Dietary Treatment in Celiac Disease: Emerging Therapeutic Options

Overview

Journal Nutrients

Date 2021 Jul 2

PMID 34201435

Citations 13

Authors

Veronica Segura

Angela Ruiz-Carnicer

Carolina Sousa

Maria de Lourdes Moreno

Affiliations

Soon will be listed here.

Abstract

To date, the only treatment for celiac disease (CD) consists of a strict lifelong gluten-free diet (GFD), which has numerous limitations in patients with CD. For this reason, dietary transgressions are frequent, implying intestinal damage and possible long-term complications. There is an unquestionable need for non-dietary alternatives to avoid damage by involuntary contamination or voluntary dietary transgressions. In recent years, different therapies and treatments for CD have been developed and studied based on the degradation of gluten in the intestinal lumen, regulation of the immune response, modulation of intestinal permeability, and induction of immunological tolerance. In this review, therapeutic lines for CD are evaluated with special emphasis on phase III and II clinical trials, some of which have promising results.

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