Aerosolized Surfactant for Preterm Infants with Respiratory Distress Syndrome

Overview

Journal Children (Basel)

Specialty Health Services

Date 2021 Jul 2

PMID 34200535

Citations 5

Authors

Mandy Brasher

Thomas M Raffay

M Douglas Cunningham

Elie G Abu Jawdeh

Affiliations

Soon will be listed here.

Abstract

Currently, the administration of surfactant to preterm infants with respiratory distress syndrome (RDS) mainly relies on intratracheal instillation; however, there is increasing evidence of aerosolized surfactant being an effective non-invasive strategy. We present a historical narrative spanning sixty years of development of aerosolization systems. We also offer an overview of the pertinent mechanisms needed to create and manage the ideal aerosolization system, with a focus on delivery, distribution, deposition, and dispersion in the context of the human lung. More studies are needed to optimize treatment with aerosolized surfactants, including determination of ideal dosages, nebulizer types, non-invasive interfaces, and breath synchronization. However, the field is rapidly evolving, and widespread clinical use may be achieved in the near future.

Citing Articles

Response to aerosolized calfactant in infants with respiratory distress syndrome; a post-hoc analysis of AERO-02 trial.

Kaluarachchi D, Zapata H, Becker H, Lasarev M, Fort P, Guthrie S J Perinatol. 2023; 43(8):998-1003.

PMID: 37429958 DOI: 10.1038/s41372-023-01717-1.

RDS-NExT workshop: consensus statements for the use of surfactant in preterm neonates with RDS.

Bhandari V, Black R, Gandhi B, Hogue S, Kakkilaya V, Mikhael M J Perinatol. 2023; 43(8):982-990.

PMID: 37188774 PMC: 10400415. DOI: 10.1038/s41372-023-01690-9.

Efficacy, dose-response, and aerosol delivery of dry powder synthetic lung surfactant treatment in surfactant-deficient rabbits and premature lambs.

Walther F, Waring A, Otieno M, DiBlasi R Respir Res. 2022; 23(1):78.

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Physiologic Effects of Instilled and Aerosolized Surfactant Using a Breath-Synchronized Nebulizer on Surfactant-Deficient Rabbits.

DiBlasi R, Micheletti K, Zimmerman J, Poli J, Fink J, Kajimoto M Pharmaceutics. 2021; 13(10).

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The Intertemporal Role of Respiratory Support in Improving Neonatal Outcomes: A Narrative Review.

Sarafidis K, Chotas W, Agakidou E, Karagianni P, Drossou V Children (Basel). 2021; 8(10).

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