Association of Drug Application and Hydration Status in Elderly Patients

Overview

Journal Nutrients

Date 2021 Jul 2

PMID 34199738

Citations 5

Authors

Laura Hoen

Daniel Pfeffer

Rico Zapf

Andrea Raabe

Janosch Hildebrand

Johannes Kraft

Stefan Kalkhof

Affiliations

Soon will be listed here.

Abstract

Due to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. Mild cognitive impairment (MCI) or dementia increase the risk of dehydration and, in turn, dehydration decreases cognitive performance. The study aims to identify and assess differences in hydration status, taking into account patients' drug treatment and diseases, using bioelectrical impedance vector analysis (BIVA), thereby revealing unfavorable aspects of prognosis. 447 geriatric patients (241 women, 206 men) including information on medication and bioelectrical impedance analysis (BIA) were investigated, which allowed studying the association between 40 drugs and the hydration status. First, patients were divided into disease groups. Renal disease and diuretic treatment were significantly different in both sexes, whereas cardiovascular patients differed exclusively for females. Next, drug enrichment was examined in either hyperhydrated or dehydrated patients. Simvastatin, candesartan, bisoprolol, amlodipine, olmesartan, furosemide, torasemide, allopurinol, mirtazapine, pantoprazole, cholecalciferol, and resveratrol showed enrichment depending on hydration status. This study demonstrated that patients can be differentiated and stratified by BIVA, taking into account medication and disease associated with hydration status. Although patients diagnosed with MCI and therefore treated with resveratrol, BIVA still showed evaluated dehydration. This is unfavorable in terms of prognosis and requires special attention.

Citing Articles

Drug Consumption and Hydration Status: Analysis of the Associations in an Elder Population.

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Characteristics of elderly diabetes patients: focus on clinical manifestation, pathogenic mechanism, and the role of traditional Chinese medicine.

Yang X, Xue C, Chen K, Gao D, Wang H, Tang C Front Pharmacol. 2024; 14:1339744.

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Physiologically based pharmacokinetic modeling of candesartan to predict the exposure in hepatic and renal impairment and elderly populations.

Guo L, Zhu X, Zhang L, Xu Y Ther Adv Drug Saf. 2023; 14:20420986231220222.

PMID: 38157240 PMC: 10752084. DOI: 10.1177/20420986231220222.

Hydration Status of Geriatric Patients Is Associated with Changes in Plasma Proteome, Especially in Proteins Involved in Coagulation.

Hoen L, Pfeffer D, Schmidt J, Kraft J, Hildebrand J, Kalkhof S Nutrients. 2023; 15(17).

PMID: 37686821 PMC: 10490147. DOI: 10.3390/nu15173789.

Urinary Hydration Biomarkers and Water Sources in Older Adults with Neurocognitive Disorder.

Queiros C, Machado F, Barros D, Sampaio J, Sampaio A, Barros R Nutrients. 2023; 15(3).

PMID: 36771256 PMC: 9921382. DOI: 10.3390/nu15030548.

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