Lifetime Weight Course As a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders

Overview

Journal Nutrients

Date 2021 Jul 2

PMID 34199265

Citations 4

Authors

Zaida Aguera

Cristina Vintro-Alcaraz

Isabel Baenas

Roser Granero

Isabel Sanchez

Jessica Sanchez-Gonzalez

Jose M Menchon

Susana Jimenez-Murcia

Janet Treasure

Fernando Fernandez-Aranda

Affiliations

Soon will be listed here.

Abstract

The association between lifetime weight fluctuations and clinical characteristics has been widely studied in populations with eating disorders (ED). However, there is a lack of literature examining the potential role of weight course as a transdiagnostic factor in ED so far. Therefore, the aim of this study is to compare ED severity and treatment outcomes among four specific BMI profiles based on BMI-trajectories across the lifespan: (a) persistent obesity (OB-OB; ( = 74)), (b) obesity in the past but currently in a normal weight range (OB-NW; = 156), (c) normal weight throughout the lifespan (NW-NW; = 756), and (d) current obesity but previously at normal weight (NW-OB; = 314). Lifetime obesity is associated with greater general psychopathology and personality traits such as low persistence and self-directedness, and high reward dependence. Additionally, greater extreme weight changes (NW-OB and OB-NW) were associated with higher psychopathology but not with greater ED severity. Higher dropout rates were found in the OB-OB group. These results shed new light on the BMI trajectory as a transdiagnostic feature playing a pivotal role in the severity and treatment outcome in patients with ED.

Citing Articles

Association of Chrononutrition Indices with Anthropometric Parameters, Academic Performance, and Psychoemotional State of Adolescents: A Cross-Sectional Study.

Borisenkov M, Tserne T, Popov S, Smirnov V, Dorogina O, Pecherkina A Nutrients. 2023; 15(21).

PMID: 37960174 PMC: 10647400. DOI: 10.3390/nu15214521.

The Role of Food Addiction and Lifetime Substance Use on Eating Disorder Treatment Outcomes.

Miranda-Olivos R, Aguera Z, Granero R, Jimenez-Murcia S, Puig-Llobet M, Lluch-Canut M Nutrients. 2023; 15(13).

PMID: 37447246 PMC: 10346594. DOI: 10.3390/nu15132919.

Temporally ordered associations between type 2 diabetes and brain disorders - a Danish register-based cohort study.

Wimberley T, Horsdal H, Brikell I, Laursen T, Astrup A, Fanelli G BMC Psychiatry. 2022; 22(1):573.

PMID: 36028833 PMC: 9413891. DOI: 10.1186/s12888-022-04163-z.

Obesity and Eating Disorders in Children and Adolescents: The Bidirectional Link.

Stabouli S, Erdine S, Suurorg L, Jankauskiene A, Lurbe E Nutrients. 2021; 13(12).

PMID: 34959873 PMC: 8705700. DOI: 10.3390/nu13124321.

References

Striegel-Moore R, Franko D, Thompson D, Barton B, Schreiber G, Daniels S . Changes in weight and body image over time in women with eating disorders. Int J Eat Disord. 2004; 36(3):315-27. DOI: 10.1002/eat.20053. View

Haines J, Neumark-Sztainer D . Prevention of obesity and eating disorders: a consideration of shared risk factors. Health Educ Res. 2006; 21(6):770-82. DOI: 10.1093/her/cyl094. View

Aguera Z, Romero X, Arcelus J, Sanchez I, Riesco N, Jimenez-Murcia S . Changes in Body Composition in Anorexia Nervosa: Predictors of Recovery and Treatment Outcome. PLoS One. 2015; 10(11):e0143012. PMC: 4658117. DOI: 10.1371/journal.pone.0143012. View

Gerlach G, Herpertz S, Loeber S . Personality traits and obesity: a systematic review. Obes Rev. 2014; 16(1):32-63. DOI: 10.1111/obr.12235. View

Fernandez-Aranda F, Treasure J, Paslakis G, Aguera Z, Gimenez M, Granero R . The impact of duration of illness on treatment nonresponse and drop-out: Exploring the relevance of enduring eating disorder concept. Eur Eat Disord Rev. 2021; 29(3):499-513. DOI: 10.1002/erv.2822. View

Zunker C, Crosby R, Mitchell J, Wonderlich S, Peterson C, Crow S . Weight suppression as a predictor variable in treatment trials of bulimia nervosa and binge eating disorder. Int J Eat Disord. 2010; 44(8):727-30. PMC: 5551980. DOI: 10.1002/eat.20859. View

Keller C, Siegrist M . Ambivalence toward palatable food and emotional eating predict weight fluctuations. Results of a longitudinal study with four waves. Appetite. 2014; 85:138-45. DOI: 10.1016/j.appet.2014.11.024. View

Riesco N, Aguera Z, Granero R, Jimenez-Murcia S, Menchon J, Fernandez-Aranda F . Other Specified Feeding or Eating Disorders (OSFED): Clinical heterogeneity and cognitive-behavioral therapy outcome. Eur Psychiatry. 2018; 54:109-116. DOI: 10.1016/j.eurpsy.2018.08.001. View

Peterson C, Thuras P, Ackard D, Mitchell J, Berg K, Sandager N . Personality dimensions in bulimia nervosa, binge eating disorder, and obesity. Compr Psychiatry. 2009; 51(1):31-6. PMC: 2838502. DOI: 10.1016/j.comppsych.2009.03.003. View

10.

Aguera Z, Riesco N, Valenciano-Mendoza E, Granero R, Sanchez I, Andreu A . Illness perception in patients with eating disorders: clinical, personality, and food addiction correlates. Eat Weight Disord. 2021; 26(7):2287-2300. DOI: 10.1007/s40519-020-01083-3. View

11.

Aguera Z, Riesco N, Jimenez-Murcia S, Islam M, Granero R, Vicente E . Cognitive behaviour therapy response and dropout rate across purging and nonpurging bulimia nervosa and binge eating disorder: DSM-5 implications. BMC Psychiatry. 2013; 13:285. PMC: 4226246. DOI: 10.1186/1471-244X-13-285. View

12.

Lowe M, Davis W, Lucks D, Annunziato R, Butryn M . Weight suppression predicts weight gain during inpatient treatment of bulimia nervosa. Physiol Behav. 2006; 87(3):487-92. DOI: 10.1016/j.physbeh.2005.11.011. View

13.

Villarejo C, Fernandez-Aranda F, Jimenez-Murcia S, Penas-Lledo E, Granero R, Penelo E . Lifetime obesity in patients with eating disorders: increasing prevalence, clinical and personality correlates. Eur Eat Disord Rev. 2012; 20(3):250-4. PMC: 3510304. DOI: 10.1002/erv.2166. View

14.

Barnes R, Blomquist K, Grilo C . Exploring pretreatment weight trajectories in obese patients with binge eating disorder. Compr Psychiatry. 2011; 52(3):312-8. PMC: 3522185. DOI: 10.1016/j.comppsych.2010.06.011. View

15.

Fouladi F, Mitchell J, Crosby R, Engel S, Crow S, Hill L . Prevalence of Alcohol and Other Substance Use in Patients with Eating Disorders. Eur Eat Disord Rev. 2015; 23(6):531-6. DOI: 10.1002/erv.2410. View

16.

Herzog D, Thomas J, Kass A, Eddy K, Franko D, Lowe M . Weight suppression predicts weight change over 5 years in bulimia nervosa. Psychiatry Res. 2010; 177(3):330-4. PMC: 2869592. DOI: 10.1016/j.psychres.2010.03.002. View

17.

Swenne I . Changes in body weight and body mass index (BMI) in teenage girls prior to the onset and diagnosis of an eating disorder. Acta Paediatr. 2001; 90(6):677-81. View

18.

Lowe M, Berner L, Swanson S, Clark V, Eddy K, Franko D . Weight suppression predicts time to remission from bulimia nervosa. J Consult Clin Psychol. 2011; 79(6):772-6. DOI: 10.1037/a0025714. View

19.

Kelley K, Preacher K . On effect size. Psychol Methods. 2012; 17(2):137-52. DOI: 10.1037/a0028086. View

20.

Lavender J, Shaw J, Crosby R, Feig E, Mitchell J, Crow S . Associations between weight suppression and dimensions of eating disorder psychopathology in a multisite sample. J Psychiatr Res. 2015; 69:87-93. PMC: 4561862. DOI: 10.1016/j.jpsychires.2015.07.021. View