Association of Fatigue, Inflammation, and Physical Activity on Gait Speed: the Long Life Family Study

Overview

Journal Aging Clin Exp Res

Publisher Springer

Specialty Geriatrics

Date 2021 Jul 1

PMID 34196949

Citations 15

Authors

Sharon W Renner

Yujia Qiao

Theresa Gmelin

Adam J Santanasto

Robert M Boudreau

Jeremy D Walston

Thomas T Perls

Kaare Christensen

Anne B Newman

Nancy W Glynn

Affiliations

Soon will be listed here.

Abstract

Background: Fatigue, inflammation, and physical activity (PA) are all independently associated with gait speed, but their directionality is not fully elucidated.

Aims: Evaluate the bidirectional associations amongst fatigue, inflammation, and PA on gait speed.

Methods: This cross sectional study included probands (n = 1280, aged 49-105) and offspring (n = 2772, aged 24-88) in the Long Life Family Study. We assessed gait speed, fatigue with the question "I could not get going", inflammation using fasting interleukin-6 (IL-6) and high sensitivity C-reactive protein (CRP), and self-reported PA as walking frequency in the past two weeks. The two generations were examined separately using linear mixed modeling.

Results: Lower fatigue, lower IL-6, and greater PA were all associated with faster gait speed in both generations (all p < 0.05); lower CRP was only associated with faster gait speed in the offspring. PA explained the association of fatigue and gait speed via a 16.1% (95% CI 9.7%, 26.7%) attenuation of the direct associations for the probands and 9.9% (95% CI 6.3%, 18.8%) in the offspring. In addition, IL-6 explained more of the association of fatigue and gait speed than the association between PA and gait speed, via a 14.9% (95% CI 9.2%, 23.4%) attenuation of the direct association in the offspring only.

Discussion: Results revealed a potential directionality from fatigue to IL-6 to PA that may lead to faster gait speed. Future work should examine these relationships longitudinally to establish temporality and causality.

Conclusions: Our findings support a signal that lowering fatigue and inflammation and increasing physical activity may delay functional decline.

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