Molecular Imaging Using Cardiac PET/CT: Opportunities to Harmonize Diagnosis and Therapy

Overview

Journal Curr Cardiol Rep

Publisher Current Science

Specialty Cardiology & Vascular Diseases

Date 2021 Jul 1

PMID 34196821

Citations 2

Authors

James T Thackeray

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Current therapeutic strategies to mitigate heart failure progression after myocardial infarction involve support of endogenous repair through molecular targets. The capacity for repair varies greatly between individuals. In this review, we will assess how cardiac PET/CT enables precise characterization of early pathogenetic processes which govern ventricle remodeling and progression to heart failure.

Recent Findings: Inflammation in the first days after myocardial infarction predicts subsequent functional decline and can influence therapy decisions. The expansion of anti-inflammatory approaches to improve outcomes after myocardial infarction may benefit from noninvasive characterization using imaging. Novel probes also allow visualization of fibroblast transdifferentiation and activation, as a precursor to ventricle remodeling. The expanding arsenal of molecular imaging agents in parallel with new treatment options provides opportunity to harmonize diagnostic imaging with precision therapy.

Citing Articles

Editorial: Case reports in cardiovascular imaging 2023.

Liga R, Korosoglou G Front Cardiovasc Med. 2024; 11:1424893.

PMID: 38867849 PMC: 11167077. DOI: 10.3389/fcvm.2024.1424893.

Regulatory Agencies and PET/CT Imaging in the Clinic.

Herscovitch P Curr Cardiol Rep. 2022; 24(10):1361-1371.

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