Effect of Tumor Red Blood Cell Immunity and Tumor Cell Cycle in Mice Bearing Solid Liver Cancer with Intelligent Cancer Zhongning Therapeutic Apparatus

Overview

Journal J Healthc Eng

Specialty Biomedical Engineering

Date 2021 Jul 1

PMID 34194680

Citations 2

Authors

Yakun Ge

Zhehan Zhang

Affiliations

Soon will be listed here.

Abstract

People's unhealthy lifestyles, especially the number of smoking and passive smoking populations, are increasing year by year and the population is aging. With the development and progress of lung cancer cell and molecular biology, the incidence rate and mortality rate of lung cancer are increasing year by year. The existing tumor biochemotherapy has rapidly developed from preliminary research and animal research to clinical research. The smart cancer Zhongning therapeutic device can induce necrosis and apoptosis of tumor cells. The effect of treating tumors is getting more and more attention. Therefore, this article focuses on the effect of the smart cancer Zhongning therapeutic device on the tumor red blood cells and tumor cell cycle of mice with solid liver cancer. The immunological effects of the drug were discussed. Forty mice were randomly divided into high-dose group, low-dose group, 5-FU group, and model group. The effects of different treatment stages on tumor red blood cell immune function and cell cycle were recorded and evaluated, and the survival rate by multiplying the positive limit method was calculated. The model group is controlled by the exact probability method, and the Pss18.0 system is used to test the hypothesis of survival rate comparison. The experimental results showed that the tumor inhibition rate in this group was 65.8%. Compared with the 5-FU group and model group, the dose group has shown an antitumor effect and had significantly improved the tumor-bearing body's antitumor red blood cell immune function and tumor cell cycle.

Citing Articles

Retracted: Effect of Tumor Red Blood Cell Immunity and Tumor Cell Cycle in Mice Bearing Solid Liver Cancer with Intelligent Cancer Zhongning Therapeutic Apparatus.

Healthcare Engineering J J Healthc Eng. 2023; 2023:9794260.

PMID: 36714407 PMC: 9883096. DOI: 10.1155/2023/9794260.

Correlation analysis of intestinal flora and immune function in patients with primary hepatocellular carcinoma.

Zhang S, Hou L, Sun Q J Gastrointest Oncol. 2022; 13(3):1308-1316.

PMID: 35837177 PMC: 9274074. DOI: 10.21037/jgo-22-427.

References

Kannan N, Sakthivel K, Guruvayoorappan C . Anti-tumor and Chemoprotective Effect of Bauhinia tomentosa by Regulating Growth Factors and Inflammatory Mediators. Asian Pac J Cancer Prev. 2016; 16(18):8119-26. DOI: 10.7314/apjcp.2015.16.18.8119. View

Mego M, Gao H, Cohen E, Anfossi S, Giordano A, Tin S . Circulating tumor cells (CTCs) are associated with abnormalities in peripheral blood dendritic cells in patients with inflammatory breast cancer. Oncotarget. 2016; 8(22):35656-35668. PMC: 5482606. DOI: 10.18632/oncotarget.10290. View

Jiang D, Chen F, Zhou H, Lu Y, Tan H, Yu S . Bioenergetic Crosstalk between Mesenchymal Stem Cells and various Ocular Cells through the intercellular trafficking of Mitochondria. Theranostics. 2020; 10(16):7260-7272. PMC: 7330858. DOI: 10.7150/thno.46332. View

Tinhofer I, Budach V, Johrens K, Keilholz U . The rationale for including immune checkpoint inhibition into multimodal primary treatment concepts of head and neck cancer. Cancers Head Neck. 2019; 1:8. PMC: 6460729. DOI: 10.1186/s41199-016-0009-6. View

Twitchell E, Tin C, Wen K, Zhang H, Becker-Dreps S, Azcarate-Peril M . Modeling human enteric dysbiosis and rotavirus immunity in gnotobiotic pigs. Gut Pathog. 2016; 8:51. PMC: 5100090. DOI: 10.1186/s13099-016-0136-y. View

Erkan D, Salmon J . The Role of Complement Inhibition in Thrombotic Angiopathies and Antiphospholipid Syndrome. Turk J Haematol. 2016; 33(1):1-7. PMC: 4805354. DOI: 10.4274/tjh.2015.0197. View

Wang Y, Wang H, Yin W, Lin Y, Zhou L, Sheng X . Novel lymphocyte to red blood cell ratio (LRR), neutrophil to red blood cell ratio (NRR), monocyte to red blood cell ratio (MRR) as predictive and prognostic biomarkers for locally advanced breast cancer. Gland Surg. 2020; 8(6):627-635. PMC: 6989912. DOI: 10.21037/gs.2019.10.10. View

Montano R, Khan N, Hou H, Seigne J, Ernstoff M, Lewis L . Cell cycle perturbation induced by gemcitabine in human tumor cells in cell culture, xenografts and bladder cancer patients: implications for clinical trial designs combining gemcitabine with a Chk1 inhibitor. Oncotarget. 2017; 8(40):67754-67768. PMC: 5620209. DOI: 10.18632/oncotarget.18834. View

Chang X, Chai Z, Zou J, Wang H, Wang Y, Zheng Y . PADI3 induces cell cycle arrest the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer. Cancer Biol Med. 2020; 16(4):729-742. PMC: 6936227. DOI: 10.20892/j.issn.2095-3941.2019.0065. View

10.

Ahmed R, Roger L, Costa Del Amo P, Miners K, Jones R, Boelen L . Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux. Cell Rep. 2016; 17(11):2811-2818. PMC: 5186732. DOI: 10.1016/j.celrep.2016.11.037. View

11.

Wong J, Cooper A . Local Ablation for Solid Tumor Liver Metastases: Techniques and Treatment Efficacy. Cancer Control. 2016; 23(1):30-5. DOI: 10.1177/107327481602300106. View

12.

Ohkuri T, Kosaka A, Ishibashi K, Kumai T, Hirata Y, Ohara K . Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site. Cancer Immunol Immunother. 2017; 66(6):705-716. PMC: 11028681. DOI: 10.1007/s00262-017-1975-1. View

13.

Zhang L, He X, Li F, Pan H, Huang X, Wen X . The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma. J Exp Clin Cancer Res. 2018; 37(1):15. PMC: 5791374. DOI: 10.1186/s13046-018-0679-5. View

14.

Jiang Q, Jin S, Jiang Y, Liao M, Feng R, Zhang L . Alzheimer's Disease Variants with the Genome-Wide Significance are Significantly Enriched in Immune Pathways and Active in Immune Cells. Mol Neurobiol. 2016; 54(1):594-600. DOI: 10.1007/s12035-015-9670-8. View

15.

Chen S, Zhao S, Wang X, Zhang L, Jiang E, Gu Y . Crocin inhibits cell proliferation and enhances cisplatin and pemetrexed chemosensitivity in lung cancer cells. Transl Lung Cancer Res. 2016; 4(6):775-83. PMC: 4700215. DOI: 10.3978/j.issn.2218-6751.2015.11.03. View

16.

Seshadri A, Brat G, Yorkgitis B, Giangola M, Keegan J, Nguyen J . Altered monocyte and NK cell phenotypes correlate with posttrauma infection. J Trauma Acute Care Surg. 2019; 87(2):337-341. DOI: 10.1097/TA.0000000000002264. View

17.

Metz E, Wuebben E, Wilder P, Cox J, Datta K, Coulter D . Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth. BMC Cancer. 2020; 20(1):941. PMC: 7528478. DOI: 10.1186/s12885-020-07370-7. View

18.

Wang M, Hu M, Li Z, He L, Song Y, Jia Q . Construction of Tb-MOF-on-Fe-MOF conjugate as a novel platform for ultrasensitive detection of carbohydrate antigen 125 and living cancer cells. Biosens Bioelectron. 2019; 142:111536. DOI: 10.1016/j.bios.2019.111536. View

19.

Maghsoudi A, Vaziri E, Feizabadi M, Mehri M . Fifty years of sheep red blood cells to monitor humoral immunity in poultry: a scientometric evaluation. Poult Sci. 2020; 99(10):4758-4768. PMC: 7598330. DOI: 10.1016/j.psj.2020.06.058. View