» Articles » PMID: 34194628

Polo-like Kinase Inhibition As a Therapeutic Target in Acute Myeloid Leukemia

Overview
Journal Oncotarget
Specialty Oncology
Date 2021 Jul 1
PMID 34194628
Citations 1
Authors
Affiliations
Soon will be listed here.
Citing Articles

Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies.

Meyer C, Smith B, Wang J, Teuscher K, Grieb B, Howard G Proc Natl Acad Sci U S A. 2024; 121(35):e2408889121.

PMID: 39167600 PMC: 11363251. DOI: 10.1073/pnas.2408889121.

References
1.
Bewersdorf J, Giri S, Wang R, Williams R, Tallman M, Zeidan A . Venetoclax as monotherapy and in combination with hypomethylating agents or low dose cytarabine in relapsed and treatment refractory acute myeloid leukemia: a systematic review and meta-analysis. Haematologica. 2020; 105(11):2659-2663. PMC: 7604631. DOI: 10.3324/haematol.2019.242826. View

2.
DiNardo C, Maiti A, Rausch C, Pemmaraju N, Naqvi K, Daver N . 10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial. Lancet Haematol. 2020; 7(10):e724-e736. PMC: 7549397. DOI: 10.1016/S2352-3026(20)30210-6. View

3.
Schnerch D, Schuler J, Follo M, Felthaus J, Wider D, Klingner K . Proteasome inhibition enhances the efficacy of volasertib-induced mitotic arrest in AML in vitro and prolongs survival in vivo. Oncotarget. 2017; 8(13):21153-21166. PMC: 5400573. DOI: 10.18632/oncotarget.15503. View

4.
Zeidan A, Ridinger M, Lin T, Becker P, Schiller G, Patel P . A Phase Ib Study of Onvansertib, a Novel Oral PLK1 Inhibitor, in Combination Therapy for Patients with Relapsed or Refractory Acute Myeloid Leukemia. Clin Cancer Res. 2020; 26(23):6132-6140. DOI: 10.1158/1078-0432.CCR-20-2586. View

5.
Renner A, Dos Santos C, Recher C, Bailly C, Creancier L, Kruczynski A . Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells. Blood. 2009; 114(3):659-62. DOI: 10.1182/blood-2008-12-195867. View