Comparative Genomic Insights Into the Taxonomic Classification, Diversity, and Secondary Metabolic Potentials of , a Genus Closely Related to

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2021 Jul 1

PMID 34194415

Citations 10

Authors

Yisong Li

Meng Wang

Zhong-Zhi Sun

Bin-Bin Xie

Affiliations

Soon will be listed here.

Abstract

While the genus (family ) has been studied as a model for bacterial secondary metabolism and genetics, its close relatives have been less studied. The genus is the second largest genus in the family . However, its taxonomic position within the family remains under debate and the secondary metabolic potential remains largely unclear. Here, we performed systematic comparative genomic and phylogenomic analyses of Firstly, the three genera within the family (, and ) showed common genomic features, including high G + C contents, high secondary metabolic potentials, and high recombination frequencies. Secondly, phylogenomic and comparative genomic analyses revealed phylogenetic distinctions and genome content differences among these three genera, supporting as a separate genus within the family. Lastly, the pan-genome analysis revealed extensive genetic diversity within the genus , while functional annotation and genome content comparison suggested genomic differentiation among lineages. This study provided new insights into genomic characteristics of the genus , and also uncovered its previously underestimated and complex secondary metabolism.

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