Effect of Iodine Supplementation in Pregnancy on Neurocognitive Development on Offspring in Iodine Deficiency Areas: a Systematic Review

Overview

Journal Arch Endocrinol Metab

Specialty Endocrinology

Date 2021 Jun 30

PMID 34191411

Citations 3

Authors

Almeida A L Machamba

Francilene M Azevedo

Karen O Fracalossi

Sylvia do C C Franceschini

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the effect of iodine supplementation during gestation on the neurocognitive development of children in areas where iodine deficiency is common.

Methods: Based on the PRISMA methodology, we conducted the search for articles in the PubMed, LILACS and Scopus databases, between March and April 2020, without limitation of dates. We used descriptors in English, Portuguese, and Spanish, without filters. Four clinical trials and four cohort articles were included in the review.

Results: The maximum supplementation was 300 μg of potassium iodide per day. The Bayley scale and Children's Communication Checklist-Short were used to assess neurodevelopment in children. There was no significant improvement in the children's mental development index and behavioural development index in the supplemented group; however, the psychomotor development index (PDI) showed improvement in the poorer gross motor skills. We found differences in the response time to sound in the supplemented group living in mild deficiency areas.

Conclusion: Daily supplementation with iodine can improve poor psychomotor development of children living in mild to moderate iodine deficiency areas. Thus, it is necessary to perform further studies to assess the effect of supplementation on neurodevelopment before, during and after gestation in mild to moderate iodine deficiency areas.

Citing Articles

Iodine Concentration in Drinking Water in the Same or Different Seasons of the Year in Brazilian Macroregions.

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How Maternal Nutritional and Mental Health Affects Child Health During Pregnancy: A Narrative Review.

Naaz A, Muneshwar K Cureus. 2023; 15(11):e48763.

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Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review.

Grossklaus R, Liesenkotter K, Doubek K, Volzke H, Gaertner R Nutrients. 2023; 15(10).

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References

Markhus M, Dahl L, Moe V, Abel M, Brantsaeter A, Oyen J . Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood. Nutrients. 2018; 10(9). PMC: 6163597. DOI: 10.3390/nu10091270. View

Zhou S, Skeaff S, Ryan P, Doyle L, Anderson P, Kornman L . The effect of iodine supplementation in pregnancy on early childhood neurodevelopment and clinical outcomes: results of an aborted randomised placebo-controlled trial. Trials. 2015; 16:563. PMC: 4675066. DOI: 10.1186/s13063-015-1080-8. View

Willoughby K, McAndrews M, Rovet J . Effects of maternal hypothyroidism on offspring hippocampus and memory. Thyroid. 2013; 24(3):576-84. DOI: 10.1089/thy.2013.0215. View

DIAMENT A . [The basis of neurologic development]. Arq Neuropsiquiatr. 1978; 36(4):285-302. DOI: 10.1590/s0004-282x1978000400001. View

Rebagliato M, Murcia M, Alvarez-Pedrerol M, Espada M, Fernandez-Somoano A, Lertxundi N . Iodine supplementation during pregnancy and infant neuropsychological development. INMA Mother and Child Cohort Study. Am J Epidemiol. 2013; 177(9):944-53. DOI: 10.1093/aje/kws333. View

Adalsteinsdottir S, Tryggvadottir E, Hrolfsdottir L, Halldorsson T, Birgisdottir B, Hreidarsdottir I . Insufficient iodine status in pregnant women as a consequence of dietary changes. Food Nutr Res. 2020; 64. PMC: 6958617. DOI: 10.29219/fnr.v64.3653. View

Rosen S, Ovadia Y, Anteby E, Fytlovich S, Aharoni D, Zamir D . Low intake of iodized salt and iodine containing supplements among pregnant women with apparently insufficient iodine status - time to change policy?. Isr J Health Policy Res. 2020; 9(1):9. PMC: 7104484. DOI: 10.1186/s13584-020-00367-4. View

Konig F, Andersson M, Hotz K, Aeberli I, Zimmermann M . Ten repeat collections for urinary iodine from spot samples or 24-hour samples are needed to reliably estimate individual iodine status in women. J Nutr. 2011; 141(11):2049-54. DOI: 10.3945/jn.111.144071. View

Abel M, Caspersen I, Meltzer H, Haugen M, Brandlistuen R, Aase H . Suboptimal Maternal Iodine Intake Is Associated with Impaired Child Neurodevelopment at 3 Years of Age in the Norwegian Mother and Child Cohort Study. J Nutr. 2017; 147(7):1314-1324. DOI: 10.3945/jn.117.250456. View

10.

Velasco I, Carreira M, Santiago P, Muela J, Garcia-Fuentes E, Sanchez-Munoz B . Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life. J Clin Endocrinol Metab. 2009; 94(9):3234-41. DOI: 10.1210/jc.2008-2652. View

11.

Johnson S, Moore T, Marlow N . Using the Bayley-III to assess neurodevelopmental delay: which cut-off should be used?. Pediatr Res. 2014; 75(5):670-4. DOI: 10.1038/pr.2014.10. View

12.

Murcia M, Rebagliato M, Iniguez C, Lopez-Espinosa M, Estarlich M, Plaza B . Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. Am J Epidemiol. 2011; 173(7):804-12. DOI: 10.1093/aje/kwq424. View

13.

Gowachirapant S, Jaiswal N, Melse-Boonstra A, Galetti V, Stinca S, MacKenzie I . Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2017; 5(11):853-863. DOI: 10.1016/S2213-8587(17)30332-7. View

14.

Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R . Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011; 21(10):1081-125. PMC: 3472679. DOI: 10.1089/thy.2011.0087. View

15.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009; 339:b2700. PMC: 2714672. DOI: 10.1136/bmj.b2700. View

16.

Lazarus J, Brown R, Daumerie C, Hubalewska-Dydejczyk A, Negro R, Vaidya B . 2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. Eur Thyroid J. 2014; 3(2):76-94. PMC: 4109520. DOI: 10.1159/000362597. View

17.

Norbury C, Nash M, Baird G, Bishop D . Using a parental checklist to identify diagnostic groups in children with communication impairment: a validation of the Children's Communication Checklist--2. Int J Lang Commun Disord. 2004; 39(3):345-64. DOI: 10.1080/13682820410001654883. View

18.

Abel M, Brandlistuen R, Caspersen I, Aase H, Torheim L, Meltzer H . Language delay and poorer school performance in children of mothers with inadequate iodine intake in pregnancy: results from follow-up at 8 years in the Norwegian Mother and Child Cohort Study. Eur J Nutr. 2018; 58(8):3047-3058. PMC: 6842354. DOI: 10.1007/s00394-018-1850-7. View

19.

Zhou S, Condo D, Ryan P, Skeaff S, Howell S, Anderson P . Association Between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months. Am J Epidemiol. 2018; 188(2):332-338. DOI: 10.1093/aje/kwy225. View

20.

Souza L, Campos R, Alves V, Cerqueira T, da Silva T, Teixeira L . Hypertension and Salt-Restrictive Diet Promotes Low Urinary Iodine Concentration in High-Risk Pregnant Women: Results from a Cross-Sectional Study Conducted After Salt Iodination Reduction in Brazil. Biol Trace Elem Res. 2020; 197(2):445-453. DOI: 10.1007/s12011-020-02028-8. View