Effect of Acupuncture on Neuroplasticity of Stroke Patients with Motor Dysfunction: A Meta-Analysis of FMRI Studies

Overview

Journal Neural Plast

Specialty Neurology

Date 2021 Jun 30

PMID 34188677

Citations 18

Authors

Qiuyi Lv

Guixing Xu

Yuxin Pan

Tongtong Liu

Xiaodong Liu

Linqing Miao

Xing Chen

Lan Jiang

Jie Chen

Yingjia He

Rong Zhang

Yihuai Zou

Affiliations

Soon will be listed here.

Abstract

Objective: To analyze the pattern of intrinsic brain activity variability that is altered by acupuncture compared with conventional treatment in stroke patients with motor dysfunction, thus providing the mechanism of stroke treatment by acupuncture.

Methods: Chinese and English articles published up to May 2020 were searched in the PubMed, Web of Science, EMBASE, and Cochrane Library databases, China National Knowledge Infrastructure, Chongqing VIP, and Wanfang Database. We only included randomized controlled trials (RCTs) using resting-state fMRI to observe the effect of acupuncture on stroke patients with motor dysfunction. R software was used to analyze the continuous variables, and Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) was used to perform an analysis of fMRI data. . A total of 7 studies comprising 143 patients in the treatment group and 138 in the control group were included in the meta-analysis. The results suggest that acupuncture treatment helps the healing process of motor dysfunction in stroke patients and exhibits hyperactivation in the bilateral basal ganglia and insula and hypoactivation in motor-related areas (especially bilateral BA6 and left BA4).

Conclusion: Acupuncture plays a role in promoting neuroplasticity in subcortical regions that are commonly affected by stroke and cortical motor areas that may compensate for motor deficits, which may provide a possible mechanism underlying the therapeutic effect of acupuncture.

Citing Articles

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References

Schaechter J, Connell B, Stason W, Kaptchuk T, Krebs D, Macklin E . Correlated change in upper limb function and motor cortex activation after verum and sham acupuncture in patients with chronic stroke. J Altern Complement Med. 2007; 13(5):527-32. DOI: 10.1089/acm.2007.6316. View

Volz L, Vollmer M, Michely J, Fink G, Rothwell J, Grefkes C . Time-dependent functional role of the contralesional motor cortex after stroke. Neuroimage Clin. 2017; 16:165-174. PMC: 5540833. DOI: 10.1016/j.nicl.2017.07.024. View

Macdonald E, van der Lee H, Pocock D, Cole C, Thomas N, VandenBerg P . A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia. Neurorehabil Neural Repair. 2007; 21(6):486-96. DOI: 10.1177/1545968307305521. View

Jang S . A review of the ipsilateral motor pathway as a recovery mechanism in patients with stroke. NeuroRehabilitation. 2009; 24(4):315-20. DOI: 10.3233/NRE-2009-0484. View

Rehme A, Eickhoff S, Rottschy C, Fink G, Grefkes C . Activation likelihood estimation meta-analysis of motor-related neural activity after stroke. Neuroimage. 2011; 59(3):2771-82. DOI: 10.1016/j.neuroimage.2011.10.023. View

Ning Y, Li K, Fu C, Ren Y, Zhang Y, Liu H . Enhanced Functional Connectivity between the Bilateral Primary Motor Cortices after Acupuncture at Yanglingquan (GB34) in Right-Hemispheric Subcortical Stroke Patients: A Resting-State fMRI Study. Front Hum Neurosci. 2017; 11:178. PMC: 5385857. DOI: 10.3389/fnhum.2017.00178. View

Carey L, Abbott D, Egan G, Bernhardt J, Donnan G . Motor impairment and recovery in the upper limb after stroke: behavioral and neuroanatomical correlates. Stroke. 2005; 36(3):625-9. DOI: 10.1161/01.STR.0000155720.47711.83. View

Neychev V, Fan X, Mitev V, Hess E, Jinnah H . The basal ganglia and cerebellum interact in the expression of dystonic movement. Brain. 2008; 131(Pt 9):2499-509. PMC: 2724906. DOI: 10.1093/brain/awn168. View

Chen Y, Chen C, Martinez R, Etnier J, Cheng Y . Habitual physical activity mediates the acute exercise-induced modulation of anxiety-related amygdala functional connectivity. Sci Rep. 2019; 9(1):19787. PMC: 6930267. DOI: 10.1038/s41598-019-56226-z. View

10.

Leigh R, Oishi K, Hsu J, Lindquist M, Gottesman R, Jarso S . Acute lesions that impair affective empathy. Brain. 2013; 136(Pt 8):2539-49. PMC: 3722353. DOI: 10.1093/brain/awt177. View

11.

Tanaka S, Honda M, Sadato N . Modality-specific cognitive function of medial and lateral human Brodmann area 6. J Neurosci. 2005; 25(2):496-501. PMC: 6725497. DOI: 10.1523/JNEUROSCI.4324-04.2005. View

12.

Dancause N, Barbay S, Frost S, Plautz E, Chen D, Zoubina E . Extensive cortical rewiring after brain injury. J Neurosci. 2005; 25(44):10167-79. PMC: 6725801. DOI: 10.1523/JNEUROSCI.3256-05.2005. View

13.

Tahmasian M, Sepehry A, Samea F, Khodadadifar T, Soltaninejad Z, Javaheripour N . Practical recommendations to conduct a neuroimaging meta-analysis for neuropsychiatric disorders. Hum Brain Mapp. 2019; 40(17):5142-5154. PMC: 6865620. DOI: 10.1002/hbm.24746. View

14.

Peng L, Zhang C, Zhou L, Zuo H, He X, Niu Y . Traditional manual acupuncture combined with rehabilitation therapy for shoulder hand syndrome after stroke within the Chinese healthcare system: a systematic review and meta-analysis. Clin Rehabil. 2017; 32(4):429-439. DOI: 10.1177/0269215517729528. View

15.

Levin M, Kleim J, Wolf S . What do motor "recovery" and "compensation" mean in patients following stroke?. Neurorehabil Neural Repair. 2009; 23(4):313-9. DOI: 10.1177/1545968308328727. View

16.

Tombari D, Loubinoux I, Pariente J, Gerdelat A, Albucher J, Tardy J . A longitudinal fMRI study: in recovering and then in clinically stable sub-cortical stroke patients. Neuroimage. 2004; 23(3):827-39. DOI: 10.1016/j.neuroimage.2004.07.058. View

17.

Zhang B, Lu J, Xia J, Wang F, Li W, Chen F . Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation. Sci Rep. 2017; 7(1):460. PMC: 5428429. DOI: 10.1038/s41598-017-00421-3. View

18.

Muller V, Cieslik E, Laird A, Fox P, Radua J, Mataix-Cols D . Ten simple rules for neuroimaging meta-analysis. Neurosci Biobehav Rev. 2017; 84:151-161. PMC: 5918306. DOI: 10.1016/j.neubiorev.2017.11.012. View

19.

Wang J, Shi W, Khiati D, Shi B, Shi X, Luo D . Acupuncture treatment on the motor area of the scalp for motor dysfunction in children with cerebral palsy: study protocol for a multicenter randomized controlled trial. Trials. 2020; 21(1):29. PMC: 6945653. DOI: 10.1186/s13063-019-3986-z. View

20.

Jacobs H, Radua J, Luckmann H, Sack A . Meta-analysis of functional network alterations in Alzheimer's disease: toward a network biomarker. Neurosci Biobehav Rev. 2013; 37(5):753-65. DOI: 10.1016/j.neubiorev.2013.03.009. View