Tropical Infections in the Context of Kidney Transplantation in Latin America

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2021 Jun 28

PMID 34181579

Authors

Lucio R Requiao-Moura

Elizabeth De Francesco Daher

Cassio R Moreira Albino

Savio de Oliveira Brilhante

Geraldo Bezerra da Silva Junior

Silvana Daher Costa

Taina Veras de Sandes-Freitas

Affiliations

Soon will be listed here.

Abstract

Reports on tropical infections among kidney transplant (KT) recipients have increased in recent years, mainly because of the growing number of KT programs located in tropical and subtropical areas, and greater mobility or migration between different areas of the world. Endemic in emerging and developing regions, like most countries in Latin America, tropical infections are an important cause of morbidity and mortality in this population. Tropical infections in KT recipients may exhibit different pathways for acquisition compared with those in nonrecipients, such as transmission through a graft and reactivation of a latent infection triggered by immunosuppression. Clinical presentation may differ compared with that in immunocompetent patients, and there are also particularities in diagnostic aspects, treatment, and prognosis. KT patients must be screened for latent infections and immunized properly. Last, drug-drug interactions between immunosuppressive agents and drugs used to treat tropical infections are an additional challenge in KT patients. In this review, we summarize the management of tropical infections in KT patients.

References

de Castro Rodrigues Ferreira F, Cristelli M, Paula M, Proenca H, Felipe C, Tedesco-Silva H . Infectious complications as the leading cause of death after kidney transplantation: analysis of more than 10,000 transplants from a single center. J Nephrol. 2017; 30(4):601-606. DOI: 10.1007/s40620-017-0379-9. View

Meije Y, Piersimoni C, Torre-Cisneros J, Dilektasli A, Aguado J . Mycobacterial infections in solid organ transplant recipients. Clin Microbiol Infect. 2014; 20 Suppl 7:89-101. DOI: 10.1111/1469-0691.12641. View

Keiser P, Nutman T . Strongyloides stercoralis in the Immunocompromised Population. Clin Microbiol Rev. 2004; 17(1):208-17. PMC: 321465. DOI: 10.1128/CMR.17.1.208-217.2004. View

Krishnamoorthy S, Kumaresan N, Zumla A . Latent tuberculosis infection and renal transplantation - Diagnosis and management. Int J Infect Dis. 2019; 80S:S73-S76. DOI: 10.1016/j.ijid.2019.01.049. View

van Griensven J, Carrillo E, Lopez-Velez R, Lynen L, Moreno J . Leishmaniasis in immunosuppressed individuals. Clin Microbiol Infect. 2014; 20(4):286-99. DOI: 10.1111/1469-0691.12556. View

Weerakkody R, Patrick J, Sheriff M . Dengue fever in renal transplant patients: a systematic review of literature. BMC Nephrol. 2017; 18(1):15. PMC: 5237298. DOI: 10.1186/s12882-016-0428-y. View

Valar C, Keitel E, Dal Pra R, Gnatta D, Santos A, BIANCO P . Parasitic infection in renal transplant recipients. Transplant Proc. 2007; 39(2):460-2. DOI: 10.1016/j.transproceed.2007.01.025. View

Siddiqui A, Berk S . Diagnosis of Strongyloides stercoralis infection. Clin Infect Dis. 2001; 33(7):1040-7. DOI: 10.1086/322707. View

Abanyie F, Gray E, Delli Carpini K, Yanofsky A, McAuliffe I, Rana M . Donor-derived Strongyloides stercoralis infection in solid organ transplant recipients in the United States, 2009-2013. Am J Transplant. 2015; 15(5):1369-75. PMC: 4747246. DOI: 10.1111/ajt.13137. View

10.

Franco-Paredes C, Jacob J, Hidron A, Rodriguez-Morales A, Kuhar D, Caliendo A . Transplantation and tropical infectious diseases. Int J Infect Dis. 2009; 14(3):e189-96. DOI: 10.1016/j.ijid.2009.04.021. View

11.

Sousa A, Lobo M, Barbosa R, Bello V . Chagas seropositive donors in kidney transplantation. Transplant Proc. 2004; 36(4):868-9. DOI: 10.1016/j.transproceed.2004.03.113. View

12.

Kransdorf E, Zakowski P, Kobashigawa J . Chagas disease in solid organ and heart transplantation. Curr Opin Infect Dis. 2014; 27(5):418-24. DOI: 10.1097/QCO.0000000000000088. View

13.

Vieira V, Pacheco L, Demetrio L, Balbi E, Bellinha T, Toledo R . Liver Transplantation for Acute Liver Failure due to Yellow Fever: A Case Report. Transplant Proc. 2019; 51(5):1625-1628. DOI: 10.1016/j.transproceed.2019.01.046. View

14.

Carrillo E, Carrasco-Anton N, Lopez-Medrano F, Salto E, Fernandez L, San Martin J . Cytokine Release Assays as Tests for Exposure to Leishmania, and for Confirming Cure from Leishmaniasis, in Solid Organ Transplant Recipients. PLoS Negl Trop Dis. 2015; 9(10):e0004179. PMC: 4619795. DOI: 10.1371/journal.pntd.0004179. View

15.

Bicalho P, Requiao-Moura L, Arruda E, Chinen R, Mello L, Bertocchi A . Long-Term Outcomes among Kidney Transplant Recipients and after Graft Failure: A Single-Center Cohort Study in Brazil. Biomed Res Int. 2019; 2019:7105084. PMC: 6466891. DOI: 10.1155/2019/7105084. View

16.

Camargo L, Kamar N, Gotuzzo E, Wright A . Schistosomiasis and Strongyloidiasis Recommendations for Solid-Organ Transplant Recipients and Donors. Transplantation. 2018; 102(2S Suppl 2):S27-S34. DOI: 10.1097/TP.0000000000002016. View

17.

Ferreira C, Silva D, Almeida P, Silva L, Carvalho V, Coutinho A . Fatal disseminated strongyloidiasis after kidney transplantation. Rev Soc Bras Med Trop. 2012; 45(5):652-4. DOI: 10.1590/s0037-86822012000500022. View

18.

Azevedo L, Lasmar E, Contieri F, Boin I, Percegona L, Saber L . Yellow fever vaccination in organ transplanted patients: is it safe? A multicenter study. Transpl Infect Dis. 2011; 14(3):237-41. DOI: 10.1111/j.1399-3062.2011.00686.x. View

19.

Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J . Zika Virus Associated with Microcephaly. N Engl J Med. 2016; 374(10):951-8. DOI: 10.1056/NEJMoa1600651. View

20.

Pierrotti L, Duarte-Neto A, Song A, Ventura C, David-Neto E, Azevedo L . Fatal Yellow Fever in a Kidney Transplant Patient. Clin Infect Dis. 2019; 70(1):144-148. DOI: 10.1093/cid/ciz389. View