Synergism of Nikkomycin Z in Combination with Diphenyl Diselenide Against Sporothrix Spp

Overview

Journal Curr Microbiol

Specialty Microbiology

Date 2021 Jun 28

PMID 34181049

Citations 1

Authors

Vanice Rodrigues Poester

Livia Silveira Munhoz

Jessica Louise Benelli

Gabriel Baracy Klafke

Cristina Wayne Nogueira

Gilson Rogerio Zeni

David A Stevens

David Larwood

Melissa Orzechowski Xavier

Affiliations

Soon will be listed here.

Abstract

We evaluated the in vitro activity of nikkomycin Z (NikZ) in combination with diphenyl diselenide (PhSe), two compounds previously shown to have anti-Sporothrix spp. activity. Eighteen isolates of Sporothrix spp. were tested in checkerboard assays. Synergism for inhibition and killing Sporothrix spp. occurred in 100% and 89% of the isolates, respectively. The anti-Sporothrix spp. activity of this combination provides a rationale for in vivo studies to evaluate the application of both compounds in sporotrichosis treatment.

Citing Articles

Treatment of Human Sporotrichosis Caused by .

Poester V, Basso R, Stevens D, Munhoz L, de Souza Rabello V, Almeida-Paes R J Fungi (Basel). 2022; 8(1).

PMID: 35050010 PMC: 8779703. DOI: 10.3390/jof8010070.

References

Chakrabarti A, Bonifaz A, Gutierrez-Galhardo M, Mochizuki T, Li S . Global epidemiology of sporotrichosis. Med Mycol. 2014; 53(1):3-14. DOI: 10.1093/mmy/myu062. View

Gremiao I, Miranda L, Reis E, Rodrigues A, Pereira S . Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission. PLoS Pathog. 2017; 13(1):e1006077. PMC: 5245785. DOI: 10.1371/journal.ppat.1006077. View

Vettorato R, Heidrich D, Fraga F, Ribeiro A, Pagani D, Timotheo C . Sporotrichosis by senso stricto with itraconazole resistance and terbinafine sensitivity observed and : Case report. Med Mycol Case Rep. 2017; 19:18-20. PMC: 5711665. DOI: 10.1016/j.mmcr.2017.10.001. View

de Bem A, de Lima Portella R, Farina M, Perottoni J, Paixao M, Nogueira C . Low toxicity of diphenyl diselenide in rabbits: a long-term study. Basic Clin Pharmacol Toxicol. 2007; 101(1):47-55. DOI: 10.1111/j.1742-7843.2007.00073.x. View

de Bem A, de Lima Portella R, Perottoni J, Becker E, Bohrer D, Paixao M . Changes in biochemical parameters in rabbits blood after oral exposure to diphenyl diselenide for long periods. Chem Biol Interact. 2006; 162(1):1-10. DOI: 10.1016/j.cbi.2006.04.005. View

Brandolt T, Madrid I, Poester V, Sanchotene K, Basso R, Baracy Klafke G . Human sporotrichosis: A zoonotic outbreak in southern Brazil, 2012-2017. Med Mycol. 2018; 57(5):527-533. DOI: 10.1093/mmy/myy082. View

Melo A, Poester V, Trapaga M, Nogueira C, Zeni G, Martinez M . Diphenyl diselenide and its interaction with antifungals against Aspergillus spp. Med Mycol. 2020; . DOI: 10.1093/mmy/myaa072. View

Pesarico A, Sartori G, dos Santos C, Neto J, Bortolotto V, Santos R . 2,2'-Dithienyl diselenide pro-oxidant activity accounts for antibacterial and antifungal activities. Microbiol Res. 2013; 168(9):563-8. DOI: 10.1016/j.micres.2013.04.009. View

Rosseti I, Rocha J, Costa M . Diphenyl diselenide (PhSe)2 inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability. J Trace Elem Med Biol. 2014; 29:289-95. DOI: 10.1016/j.jtemb.2014.08.001. View

10.

Felix-Contreras C, Alba-Fierro C, Rios-Castro E, Luna-Martinez F, Cuellar-Cruz M, Ruiz-Baca E . Proteomic analysis of Sporothrix schenckii cell wall reveals proteins involved in oxidative stress response induced by menadione. Microb Pathog. 2020; 141:103987. DOI: 10.1016/j.micpath.2020.103987. View

11.

Gremiao I, Schubach T, Pereira S, Rodrigues A, Honse C, Barros M . Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole. Aust Vet J. 2011; 89(9):346-51. DOI: 10.1111/j.1751-0813.2011.00804.x. View

12.

Carlos I, Sassa M, Sgarbi D, Placeres M, Maia D . Current research on the immune response to experimental sporotrichosis. Mycopathologia. 2009; 168(1):1-10. DOI: 10.1007/s11046-009-9190-z. View

13.

Sanchotene K, Brandolt T, Baracy Klafke G, Poester V, Xavier M . In vitro susceptibility of Sporothrix brasiliensis: Comparison of yeast and mycelial phases. Med Mycol. 2017; 55(8):869-876. DOI: 10.1093/mmy/myw143. View

14.

Prigol M, Bruning C, Martini F, Nogueira C . Comparative excretion and tissue distribution of selenium in mice and rats following treatment with diphenyl diselenide. Biol Trace Elem Res. 2012; 150(1-3):272-7. DOI: 10.1007/s12011-012-9464-z. View