The Interface of and the Gut Microbiome

Overview

Journal Gut Microbes

Specialties Gastroenterology
Microbiology

Date 2021 Jun 28

PMID 34180341

Citations 19

Authors

Jennifer Y Cho

Rui Liu

John C Macbeth

Ansel Hsiao

Affiliations

Soon will be listed here.

Abstract

The bacterium is the etiologic agent of the severe human diarrheal disease cholera. The gut microbiome, or the native community of microorganisms found in the human gastrointestinal tract, is increasingly being recognized as a factor in driving susceptibility to infection, fitness, and host interactions of this pathogen. Here, we review a subset of the emerging studies in how gut microbiome structure and microbial function are able to drive virulence gene regulation, metabolism, and modulate host immune responses to cholera infection and vaccination. Improved mechanistic understanding of commensal-pathogen interactions offers new perspectives in the design of prophylactic and therapeutic approaches for cholera control.

Citing Articles

Pathways of exposure to Vibrio Cholerae in an urban informal settlement in Nairobi, Kenya.

Kering K, Wang Y, Mbae C, Mugo M, Ongadi B, Odityo G PLOS Glob Public Health. 2024; 4(8):e0002880.

PMID: 39163285 PMC: 11335117. DOI: 10.1371/journal.pgph.0002880.

Use of zebrafish to identify host responses specific to type VI secretion system mediated interbacterial antagonism.

Virgo M, Mostowy S, Ho B PLoS Pathog. 2024; 20(7):e1012384.

PMID: 39024393 PMC: 11288455. DOI: 10.1371/journal.ppat.1012384.

Animal and In Vitro Models as Powerful Tools to Decipher the Effects of Enteric Pathogens on the Human Gut Microbiota.

Calvigioni M, Mazzantini D, Celandroni F, Ghelardi E Microorganisms. 2024; 12(1).

PMID: 38257894 PMC: 10818369. DOI: 10.3390/microorganisms12010067.

Immunostimulating Commensal Bacteria and Their Potential Use as Therapeutics.

McCuaig B, Goto Y Int J Mol Sci. 2023; 24(21).

PMID: 37958628 PMC: 10647581. DOI: 10.3390/ijms242115644.

Magnetic chitin beads (MCB) coated with reveals transcriptome dynamics in adult mice with a complex gut microbiota.

Qin Z, Chen G, Bao W, Ma Y, Yang X, Yi C Gut Microbes. 2023; 15(2):2274125.

PMID: 37934002 PMC: 10631443. DOI: 10.1080/19490976.2023.2274125.

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