Comparison of Effect of Crush or Transection Peripheral Nerve Lesion on Lumbar Spinal Cord Synaptic Plasticity and Microglial Dynamics

Overview

Journal IBRO Neurosci Rep

Specialty Neurology

Date 2021 Jun 28

PMID 34179871

Citations 7

Authors

Raquel M P Campos

Maria Carolina Barbosa-Silva

Victor T Ribeiro-Resende

Affiliations

Soon will be listed here.

Abstract

Summary Of Statement: Here, we demonstrated that acute plasticity in the lumbar spinal cord (LSC) did not differ between crush and transection of peripheral nerve, and that microglial reactivity in the LSC was important after both injury types.

Citing Articles

Synapse Regulation.

Vecchiarelli H, Lopes L, Paolicelli R, Stevens B, Wake H, Tremblay M Adv Neurobiol. 2024; 37:179-208.

PMID: 39207693 DOI: 10.1007/978-3-031-55529-9_11.

Expression of ChAT, Iba-1, and nNOS in the Central Nervous System following Facial Nerve Injury.

Lee J, Yoo M, Kim Y, Kim S, Yeo S Antioxidants (Basel). 2024; 13(5).

PMID: 38790700 PMC: 11118893. DOI: 10.3390/antiox13050595.

Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia.

Rotterman T, Haley-Johnson Z, Pottorf T, Chopra T, Chang E, Zhang S Cell Rep. 2024; 43(2):113776.

PMID: 38367237 PMC: 10947500. DOI: 10.1016/j.celrep.2024.113776.

DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses.

Asghari Adib E, Shadrach J, Reilly-Jankowiak L, Dwivedi M, Rogers A, Shahzad S Cell Rep. 2024; 43(2):113801.

PMID: 38363678 PMC: 11088462. DOI: 10.1016/j.celrep.2024.113801.

Region-specific response of central microglial cells to sciatic nerve demyelination through sensory and motor pathways.

Wu S, Su Y, Wang Y, Wang J, Xu D, Liu Y Histol Histopathol. 2023; 39(6):771-781.

PMID: 38051019 DOI: 10.14670/HH-18-681.

References

Thornton M, Shawcross S, Mantovani C, Kingham P, Birchall M, Terenghi G . Neurotrophins 3 and 4 differentially regulate NCAM, L1 and N-cadherin expression during peripheral nerve regeneration. Biotechnol Appl Biochem. 2007; 49(Pt 2):165-74. DOI: 10.1042/BA20070040. View

Jones E . Cortical and subcortical contributions to activity-dependent plasticity in primate somatosensory cortex. Annu Rev Neurosci. 2000; 23:1-37. DOI: 10.1146/annurev.neuro.23.1.1. View

Young K, Morrison H . Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ. J Vis Exp. 2018; (136). PMC: 6103256. DOI: 10.3791/57648. View

BLINZINGER K, KREUTZBERG G . Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Z Zellforsch Mikrosk Anat. 1968; 85(2):145-57. DOI: 10.1007/BF00325030. View

Nikodemova M, Watters J, Jackson S, Yang S, Duncan I . Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII. J Biol Chem. 2007; 282(20):15208-16. DOI: 10.1074/jbc.M611907200. View

Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S . Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010; 330(6005):841-5. PMC: 3719181. DOI: 10.1126/science.1194637. View

Mecha M, Carrillo-Salinas F, Feliu A, Mestre L, Guaza C . Microglia activation states and cannabinoid system: Therapeutic implications. Pharmacol Ther. 2016; 166:40-55. DOI: 10.1016/j.pharmthera.2016.06.011. View

Aldskogius H, Kozlova E . Central neuron-glial and glial-glial interactions following axon injury. Prog Neurobiol. 1998; 55(1):1-26. DOI: 10.1016/s0301-0082(97)00093-2. View

Jones R, Lynch M . How dependent is synaptic plasticity on microglial phenotype?. Neuropharmacology. 2014; 96(Pt A):3-10. DOI: 10.1016/j.neuropharm.2014.08.012. View

10.

Orihuela R, McPherson C, Harry G . Microglial M1/M2 polarization and metabolic states. Br J Pharmacol. 2015; 173(4):649-65. PMC: 4742299. DOI: 10.1111/bph.13139. View

11.

Lisi L, Ciotti G, Braun D, Kalinin S, Curro D, Dello Russo C . Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial polarization in human glioblastoma and the surrounding normal parenchyma. Neurosci Lett. 2017; 645:106-112. DOI: 10.1016/j.neulet.2017.02.076. View

12.

Walker F, Beynon S, Jones K, Zhao Z, Kongsui R, Cairns M . Dynamic structural remodelling of microglia in health and disease: a review of the models, the signals and the mechanisms. Brain Behav Immun. 2014; 37:1-14. DOI: 10.1016/j.bbi.2013.12.010. View

13.

Aldskogius H . Mechanisms and consequences of microglial responses to peripheral axotomy. Front Biosci (Schol Ed). 2011; 3(3):857-68. DOI: 10.2741/192. View

14.

Yamada J, Jinno S . Novel objective classification of reactive microglia following hypoglossal axotomy using hierarchical cluster analysis. J Comp Neurol. 2012; 521(5):1184-201. DOI: 10.1002/cne.23228. View

15.

Woolf C, Shortland P, Reynolds M, Ridings J, Doubell T, Coggeshall R . Reorganization of central terminals of myelinated primary afferents in the rat dorsal horn following peripheral axotomy. J Comp Neurol. 1995; 360(1):121-34. DOI: 10.1002/cne.903600109. View

16.

Popiolek-Barczyk K, Rojewska E, Jurga A, Makuch W, Zador F, Borsodi A . Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain. Biomed Res Int. 2014; 2014:762930. PMC: 4168034. DOI: 10.1155/2014/762930. View

17.

Wall J, Kaas J, Sur M, Nelson R, Felleman D, Merzenich M . Functional reorganization in somatosensory cortical areas 3b and 1 of adult monkeys after median nerve repair: possible relationships to sensory recovery in humans. J Neurosci. 1986; 6(1):218-33. PMC: 6568627. View

18.

Wang N, Mi X, Gao B, Gu J, Wang W, Zhang Y . Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus. Neuroscience. 2014; 287:144-56. DOI: 10.1016/j.neuroscience.2014.12.021. View

19.

Berg A, Zelano J, Stephan A, Thams S, Barres B, Pekny M . Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3. Exp Neurol. 2012; 237(1):8-17. DOI: 10.1016/j.expneurol.2012.06.008. View

20.

Emirandetti A, Simoes G, Zanon R, Oliveira A . Spinal motoneuron synaptic plasticity after axotomy in the absence of inducible nitric oxide synthase. J Neuroinflammation. 2010; 7:31. PMC: 2885347. DOI: 10.1186/1742-2094-7-31. View