Exosomes in Intestinal Inflammation

Overview

Journal Front Pharmacol

Date 2021 Jun 28

PMID 34177577

Citations 22

Authors

Kanchana K Ayyar

Alan C Moss

Affiliations

Soon will be listed here.

Abstract

Exosomes are 30-150 nm sized vesicles released by a variety of cells, and are found in most physiological compartments (feces, blood, urine, saliva, breast milk). They can contain different cargo, including nucleic acids, proteins and lipids. In Inflammatory Bowel Disease (IBD), a distinct exosome profile can be detected in blood and fecal samples. In addition, circulating exosomes can carry targets on their surface for monoclonal antibodies used as IBD therapy. This review aims to understand the exosome profile in humans and other mammals, the cargo contained in them, the effect of exosomes on the gut, and the application of exosomes in IBD therapy.

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References

Maas S, Breakefield X, Weaver A . Extracellular Vesicles: Unique Intercellular Delivery Vehicles. Trends Cell Biol. 2016; 27(3):172-188. PMC: 5318253. DOI: 10.1016/j.tcb.2016.11.003. View

Xie M, Hou L, Sun J, Zeng B, Xi Q, Luo J . Porcine Milk Exosome MiRNAs Attenuate LPS-Induced Apoptosis through Inhibiting TLR4/NF-κB and p53 Pathways in Intestinal Epithelial Cells. J Agric Food Chem. 2019; 67(34):9477-9491. DOI: 10.1021/acs.jafc.9b02925. View

Munich S, Sobo-Vujanovic A, Buchser W, Beer-Stolz D, Vujanovic N . Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands. Oncoimmunology. 2012; 1(7):1074-1083. PMC: 3494621. DOI: 10.4161/onci.20897. View

Peterson L, Artis D . Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014; 14(3):141-53. DOI: 10.1038/nri3608. View

Zamrik S, Giachero F, Heldmann M, Hensel K, Wirth S, Jenke A . Impact of an In-House Pediatric Surgery Unit and Human Milk Centered Enteral Nutrition on Necrotizing Enterocolitis. Biomed Res Int. 2018; 2018:5042707. PMC: 6258105. DOI: 10.1155/2018/5042707. View

Fabrega M, Aguilera L, Gimenez R, Varela E, Canas M, Antolin M . Activation of Immune and Defense Responses in the Intestinal Mucosa by Outer Membrane Vesicles of Commensal and Probiotic Escherichia coli Strains. Front Microbiol. 2016; 7:705. PMC: 4863414. DOI: 10.3389/fmicb.2016.00705. View

Liao Y, Du X, Li J, Lonnerdal B . Human milk exosomes and their microRNAs survive digestion in vitro and are taken up by human intestinal cells. Mol Nutr Food Res. 2017; 61(11). DOI: 10.1002/mnfr.201700082. View

Boehm M, Simson D, Escher U, Schmidt A, Bereswill S, Tegtmeyer N . Function of Serine Protease HtrA in the Lifecycle of the Foodborne Pathogen . Eur J Microbiol Immunol (Bp). 2018; 8(3):70-77. PMC: 6186014. DOI: 10.1556/1886.2018.00011. View

Gisbert J, Chaparro M . Predictors of Primary Response to Biologic Treatment [Anti-TNF, Vedolizumab, and Ustekinumab] in Patients With Inflammatory Bowel Disease: From Basic Science to Clinical Practice. J Crohns Colitis. 2019; 14(5):694-709. DOI: 10.1093/ecco-jcc/jjz195. View

10.

Ayyar K, Reddy K . Transcription factor CCAAT/enhancer-binding protein-β upregulates microRNA, let-7f-1 in human endocervical cells. Am J Reprod Immunol. 2017; 78(6). DOI: 10.1111/aji.12759. View

11.

Ayyar K, Reddy K . MAPK and NF-κB signalling pathways regulate the expression of miRNA, let-7f in human endocervical epithelial cells. J Cell Biochem. 2018; 119(6):4751-4759. DOI: 10.1002/jcb.26665. View

12.

Barile L, Vassalli G . Exosomes: Therapy delivery tools and biomarkers of diseases. Pharmacol Ther. 2017; 174:63-78. DOI: 10.1016/j.pharmthera.2017.02.020. View

13.

Domenis R, Marino M, Cifu A, Scardino G, Curcio F, Fabris M . Circulating exosomes express α4β7 integrin and compete with CD4+ T cells for the binding to Vedolizumab. PLoS One. 2020; 15(11):e0242342. PMC: 7661055. DOI: 10.1371/journal.pone.0242342. View

14.

Walker W, Iyengar R . Breast milk, microbiota, and intestinal immune homeostasis. Pediatr Res. 2014; 77(1-2):220-8. DOI: 10.1038/pr.2014.160. View

15.

Ismail S, Hampton M, Keenan J . Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells. Infect Immun. 2003; 71(10):5670-5. PMC: 201067. DOI: 10.1128/IAI.71.10.5670-5675.2003. View

16.

Zheng X, Chen F, Zhang Q, Liu Y, You P, Sun S . Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease. Protein Cell. 2017; 8(9):686-695. PMC: 5563283. DOI: 10.1007/s13238-017-0413-7. View

17.

Baier S, Nguyen C, Xie F, Wood J, Zempleni J . MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers. J Nutr. 2014; 144(10):1495-500. PMC: 4162473. DOI: 10.3945/jn.114.196436. View

18.

Deng Z, Rong Y, Teng Y, Mu J, Zhuang X, Tseng M . Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase. Mol Ther. 2017; 25(7):1641-1654. PMC: 5498816. DOI: 10.1016/j.ymthe.2017.01.025. View

19.

Edgar J . Q&A: What are exosomes, exactly?. BMC Biol. 2016; 14:46. PMC: 4906597. DOI: 10.1186/s12915-016-0268-z. View

20.

Samanta S, Rajasingh S, Drosos N, Zhou Z, Dawn B, Rajasingh J . Exosomes: new molecular targets of diseases. Acta Pharmacol Sin. 2017; 39(4):501-513. PMC: 5888687. DOI: 10.1038/aps.2017.162. View