Circulating ERBB3 Levels Are Inversely Associated with the Risk of Overweight-related Hypertension: a Cross-sectional Study

Overview

Journal BMC Endocr Disord

Publisher Biomed Central

Specialty Endocrinology

Date 2021 Jun 28

PMID 34176482

Authors

Lijun Zhu

Zhengmei Fang

Yuelong Jin

Weiwei Chang

Mengyun Huang

Yan Chen

Yingshui Yao

Affiliations

Soon will be listed here.

Abstract

Background: Hypertension and overweight are independent risk factors for cardiovascular disease, and overweight increase the risk of developing high blood pressure. ERBB3( also known as HER3) plays a considerable role in the development of cardiovascular diseases. However, the effect of ERBB3 levels in hypertensive overweight patients is unknown. The aim of this study was to assess the association between ERBB3 levels and hypertension in overweight Chinese patients.

Methods: We evaluated the height,weight, blood pressure, biochemical indicators, and ERBB3 levels in 128 Chinese adults aged 33-79 years. Plasma ERBB3 levels were assessed by the enzyme-linked immunosorbent assay, and body mass index(BMI) was calculated as body weight divided by height squared. Participants were allocated into three groups according to blood pressure and BMI: healthy control (CNT, n = 31; normotensive and non-overweight), hypertension (HT, n = 33; hypertension and non-overweight), and hypertension with overweight (HTO, n = 64; hypertension and overweight). Statistical significance was defined as a two-tailed P < 0.05.

Results: There was no significant difference in mean ERBB3 levels among the three groups, although a linear decrease from CNT (1.13 ± 0.36), HT (1.03 ± 0.36), to HTO (0.84 ± 0.26 ng/mL) was observed in men (P = 0.007). Among the drinking population, the ERBB3 level was significantly reduced in the HTO group as compared with those of the CNT and HT groups (0.76 ± 0.23 versus 1.18 ± 0.37 and 1.20 ± 0.30, respectively). ERBB3 levels were negatively correlated with diastolic blood pressure in men (r= - 0.293, P = 0.012), smoking (r= - 0.47, P = 0.004), and drinking (r = - 0.387, P = 0.008). BMI in men and among drinkers, and uric acid among drinkers were negatively correlated with ERBB3 levels. Multivariate conditional logistic regression showed that plasma ERBB3 levels were associated with a reduced risk of HTO in men [odds ratio (OR) 0.054; 95 % confidence interval (CI): 0.007-0.412) and drinkers (OR 0.002; 95 % CI: 0.000-0.101).

Conclusions: ERBB3 may contribute to the pathogenesis of hypertension in overweight patients, with BMI, gender, and drinking all potentially modulating the process.

Citing Articles

Alaamri S, Serafi A, Hussain Z, Bafail S, Bafail M, Demirkhanyan L Pathophysiology. 2025; 32(1).

PMID: 39982363 PMC: 11843874. DOI: 10.3390/pathophysiology32010007.

References

Ottolini M, Hong K, Cope E, Daneva Z, DeLalio L, Sokolowski J . Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity. Circulation. 2020; 141(16):1318-1333. PMC: 7195859. DOI: 10.1161/CIRCULATIONAHA.119.043385. View

Wiinberg N, Hoegholm A, Christensen H, Bang L, Mikkelsen K, Nielsen P . 24-h ambulatory blood pressure in 352 normal Danish subjects, related to age and gender. Am J Hypertens. 1995; 8(10 Pt 1):978-86. DOI: 10.1016/0895-7061(95)00216-2. View

Wilson P, DAgostino R, Sullivan L, Parise H, Kannel W . Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med. 2002; 162(16):1867-72. DOI: 10.1001/archinte.162.16.1867. View

Yarden Y, Sliwkowski M . Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001; 2(2):127-37. DOI: 10.1038/35052073. View

Jin Q, Esteva F . Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer. J Mammary Gland Biol Neoplasia. 2008; 13(4):485-98. DOI: 10.1007/s10911-008-9107-3. View

Feng R, Zhao C, Wang C, Niu Y, Li K, Guo F . BMI is strongly associated with hypertension, and waist circumference is strongly associated with type 2 diabetes and dyslipidemia, in northern Chinese adults. J Epidemiol. 2012; 22(4):317-23. PMC: 3798650. DOI: 10.2188/jea.je20110120. View

Ma J, Wang Z, Dong B, Song Y, Hu P, Zhang B . Quantifying the relationships of blood pressure with weight, height and body mass index in Chinese children and adolescents. J Paediatr Child Health. 2011; 48(5):413-8. DOI: 10.1111/j.1440-1754.2011.02221.x. View

Ricco R, Ricco R, Queluz M, de Paula M, Atique P, Custodio R . IGF-1R mRNA expression is increased in obese children. Growth Horm IGF Res. 2017; 39:1-5. DOI: 10.1016/j.ghir.2017.11.001. View

Maitusong B, Xie X, Ma Y, Fu Z, Yang Y, Li X . Association between ErbB3 genetic polymorphisms and coronary artery disease in the Han and Uyghur populations of China. Int J Clin Exp Med. 2015; 8(9):16520-7. PMC: 4659067. View

10.

Ryzhov S, Matafonov A, Galindo C, Zhang Q, Tran T, Lenihan D . ERBB signaling attenuates proinflammatory activation of nonclassical monocytes. Am J Physiol Heart Circ Physiol. 2017; 312(5):H907-H918. PMC: 5451588. DOI: 10.1152/ajpheart.00486.2016. View

11.

Cox L, Birnbaum S, VandeBerg J . Identification of candidate genes regulating HDL cholesterol using a chromosomal region expression array. Genome Res. 2002; 12(11):1693-702. PMC: 187541. DOI: 10.1101/gr.333502. View

12.

Freedman D, Jacobsen S, Barboriak J, Sobocinski K, Anderson A, Kissebah A . Body fat distribution and male/female differences in lipids and lipoproteins. Circulation. 1990; 81(5):1498-506. DOI: 10.1161/01.cir.81.5.1498. View

13.

Linhart C, Tukana I, Lin S, Taylor R, Morrell S, Vatucawaqa P . Continued increases in hypertension over three decades in Fiji, and the influence of obesity. J Hypertens. 2015; 34(3):402-9. PMC: 4732009. DOI: 10.1097/HJH.0000000000000807. View

14.

Hedhli N, Kalinowski A, Russell K . Cardiovascular effects of neuregulin-1/ErbB signaling: role in vascular signaling and angiogenesis. Curr Pharm Des. 2013; 20(30):4899-905. DOI: 10.2174/1381612819666131125151058. View

15.

Attard S, Herring A, Zhang B, Du S, Popkin B, Gordon-Larsen P . Associations between age, cohort, and urbanization with SBP and DBP in China: a population-based study across 18 years. J Hypertens. 2015; 33(5):948-56. PMC: 4412782. DOI: 10.1097/HJH.0000000000000522. View

16.

Kannel W . Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA. 1996; 275(20):1571-6. View

17.

Rahmouni K . Obesity-associated hypertension: recent progress in deciphering the pathogenesis. Hypertension. 2014; 64(2):215-21. PMC: 4184930. DOI: 10.1161/HYPERTENSIONAHA.114.00920. View

18.

Zou Z, Yang Y, Wang S, Dong B, Li X, Ma J . The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children. Br J Nutr. 2016; 116(1):45-51. DOI: 10.1017/S0007114516001744. View

19.

Shiue I . Self and environmental exposures to drinking, smoking, gambling or video game addiction are associated with adult hypertension, heart and cerebrovascular diseases, allergy, self-rated health and happiness: Japanese General Social Survey, 2010. Int J Cardiol. 2015; 181:403-12. DOI: 10.1016/j.ijcard.2014.12.071. View

20.

Rahman A, Henry K, Herman K, Thompson A, Isles H, Tulotta C . Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation. Elife. 2019; 8. PMC: 6839918. DOI: 10.7554/eLife.50990. View