Thalamus and Claustrum Control Parallel Layer 1 Circuits in Retrosplenial Cortex

Overview

Journal Elife

Specialty Biology

Date 2021 Jun 25

PMID 34170817

Citations 19

Authors

Ellen Kw Brennan

Izabela Jedrasiak-Cape

Sameer Kailasa

Sharena P Rice

Shyam Kumar Sudhakar

Omar J Ahmed

Affiliations

Soon will be listed here.

Abstract

The granular retrosplenial cortex (RSG) is critical for both spatial and non-spatial behaviors, but the underlying neural codes remain poorly understood. Here, we use optogenetic circuit mapping in mice to reveal a double dissociation that allows parallel circuits in superficial RSG to process disparate inputs. The anterior thalamus and dorsal subiculum, sources of spatial information, strongly and selectively recruit small low-rheobase (LR) pyramidal cells in RSG. In contrast, neighboring regular-spiking (RS) cells are preferentially controlled by claustral and anterior cingulate inputs, sources of mostly non-spatial information. Precise sublaminar axonal and dendritic arborization within RSG layer 1, in particular, permits this parallel processing. Observed thalamocortical synaptic dynamics enable computational models of LR neurons to compute the speed of head rotation, despite receiving head direction inputs that do not explicitly encode speed. Thus, parallel input streams identify a distinct principal neuronal subtype ideally positioned to support spatial orientation computations in the RSG.

Citing Articles

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