First Complete Genome Sequence and Molecular Characterization of Canine Morbillivirus Isolated in Central Brazil

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jun 23

PMID 34158515

Citations 4

Authors

Vivaldo Gomes da Costa

Marielena Vogel Saivish

Priscila Gomes de Oliveira

Abelardo Silva-Junior

Marcos Lazaro Moreli

Ricardo Henrique Kruger

Affiliations

Soon will be listed here.

Abstract

The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil.

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