Removal of Two Cytostatic Drugs: Bleomycin and Vincristine by White-rot Fungi - a Sorption Study

Overview

Journal J Environ Health Sci Eng

Publisher Springer

Date 2021 Jun 21

PMID 34150265

Citations 2

Authors

Marcelina Jureczko

Wioletta Przystas

Affiliations

Soon will be listed here.

Abstract

Purpose: Cytostatic drugs cannot be easily removed by conventional sewage treatment plants, resulting in their ultimate release into aquatic systems where they become a threat. Thus, new technologies which can be used to eliminate these drugs more effectively before they enter the environment are increasingly important. Fungal treatment of wastewaters is a promising and environmentally friendly technology for pharmaceutical remediation. The aim of this work is to examine the biosorption of two cytostatics, bleomycin and vincristine, in the aqueous solution by fungal biomass.

Methods: Five white-rot fungi were used in this study: (CB13), (CB15), (CB14), (BWPH), and (CB8). Tests were conducted on different types of biomass (alive and dead - autoclaved) and in various physico-chemical conditions: varied drug concentrations (5, 10 and 15 mg/L), temperatures (from 15.4 to 29.6 °C), and pH (from 3.2 to 8.8).

Results: The results showed that among alive biomass, (CB8) had the greatest sorption ability for bleomycin and (CB14) worked best for vincristine. The tested sorption process could be described by a pseudo-second order kinetics model. Sorption equilibrium studies demonstrated that for bleomycin Redlich-Peterson, while for vincristine Langmuir model fitted best. The thermodynamic studies showed that the sorption process was endothermic chemisorption for bleomycin, and exothermic physisorption for vincristine. For both drugs the sorption ability increased with an increase of the pH value.

Conclusion: The biosorption on fungal biomass is a favorable alternative to conventional wastewater treatment processes for anticancer drug removal.

Citing Articles

Optimizing Bioaugmentation for Pharmaceutical Stabilization of Sewage Sludge: A Study on Short-Term Composting Under Real Conditions.

Angeles-De Paz G, Cubero-Cardoso J, Pozo C, Calvo C, Aranda E, Robledo-Mahon T J Fungi (Basel). 2025; 11(1).

PMID: 39852486 PMC: 11766644. DOI: 10.3390/jof11010067.

The potential of fungi in the bioremediation of pharmaceutically active compounds: a comprehensive review.

Amobonye A, Aruwa C, Aransiola S, Omame J, Alabi T, Lalung J Front Microbiol. 2023; 14:1207792.

PMID: 37502403 PMC: 10369004. DOI: 10.3389/fmicb.2023.1207792.

Performance of Pristine Magnetized Orange Peels Biochar Adapted to Adsorptive Removal of Daunorubicin: Eco-Structuring, Kinetics and Equilibrium Studies.

El-Shafie A, Barah F, Abouseada M, El-Azazy M Nanomaterials (Basel). 2023; 13(9).

PMID: 37176989 PMC: 10179814. DOI: 10.3390/nano13091444.

References

Olicon-Hernandez D, Gonzalez-Lopez J, Aranda E . Overview on the Biochemical Potential of Filamentous Fungi to Degrade Pharmaceutical Compounds. Front Microbiol. 2017; 8:1792. PMC: 5611422. DOI: 10.3389/fmicb.2017.01792. View

Ferrando-Climent L, Cruz-Morato C, Marco-Urrea E, Vicent T, Sarra M, Rodriguez-Mozaz S . Non conventional biological treatment based on Trametes versicolor for the elimination of recalcitrant anticancer drugs in hospital wastewater. Chemosphere. 2015; 136:9-19. DOI: 10.1016/j.chemosphere.2015.03.051. View

Marco-Urrea E, Perez-Trujillo M, Cruz-Morato C, Caminal G, Vicent T . White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC-DAD-MS and NMR. Chemosphere. 2009; 78(4):474-81. DOI: 10.1016/j.chemosphere.2009.10.009. View

Lenz K, Mahnik S, Weissenbacher N, Mader R, Krenn P, Hann S . Monitoring, removal and risk assessment of cytostatic drugs in hospital wastewater. Water Sci Technol. 2007; 56(12):141-9. DOI: 10.2166/wst.2007.828. View

Castellet-Rovira F, Lucas D, Villagrasa M, Rodriguez-Mozaz S, Barcelo D, Sarra M . Stropharia rugosoannulata and Gymnopilus luteofolius: Promising fungal species for pharmaceutical biodegradation in contaminated water. J Environ Manage. 2017; 207:396-404. DOI: 10.1016/j.jenvman.2017.07.052. View

Magdaleno A, Juarez A, Dragani V, Saenz M, Paz M, Moretton J . Ecotoxicological and genotoxic evaluation of Buenos Aires city (Argentina) hospital wastewater. J Toxicol. 2014; 2014:248461. PMC: 4158310. DOI: 10.1155/2014/248461. View

Fent K, Weston A, Caminada D . Ecotoxicology of human pharmaceuticals. Aquat Toxicol. 2005; 76(2):122-59. DOI: 10.1016/j.aquatox.2005.09.009. View

Aherne G, Hardcastle A, Nield A . Cytotoxic drugs and the aquatic environment: estimation of bleomycin in river and water samples. J Pharm Pharmacol. 1990; 42(10):741-2. DOI: 10.1111/j.2042-7158.1990.tb06574.x. View

Naghdi M, Taheran M, Brar S, Kermanshahi-Pour A, Verma M, Surampalli R . Removal of pharmaceutical compounds in water and wastewater using fungal oxidoreductase enzymes. Environ Pollut. 2017; 234:190-213. DOI: 10.1016/j.envpol.2017.11.060. View

10.

Mahnik S, Lenz K, Weissenbacher N, Mader R, Fuerhacker M . Fate of 5-fluorouracil, doxorubicin, epirubicin, and daunorubicin in hospital wastewater and their elimination by activated sludge and treatment in a membrane-bio-reactor system. Chemosphere. 2006; 66(1):30-7. DOI: 10.1016/j.chemosphere.2006.05.051. View

11.

Palli L, Castellet-Rovira F, Perez-Trujillo M, Caniani D, Sarra-Adroguer M, Gori R . Preliminary evaluation of Pleurotus ostreatus for the removal of selected pharmaceuticals from hospital wastewater. Biotechnol Prog. 2017; 33(6):1529-1537. DOI: 10.1002/btpr.2520. View

12.

Rodriguez-Rodriguez C, Jelic A, Pereira M, Sousa D, Petrovic M, Alves M . Bioaugmentation of sewage sludge with Trametes versicolor in solid-phase biopiles produces degradation of pharmaceuticals and affects microbial communities. Environ Sci Technol. 2012; 46(21):12012-20. DOI: 10.1021/es301788n. View

13.

Maurya N, Mittal A, Cornel P, Rother E . Biosorption of dyes using dead macro fungi: effect of dye structure, ionic strength and pH. Bioresour Technol. 2005; 97(3):512-21. DOI: 10.1016/j.biortech.2005.02.045. View

14.

Rafatullah M, Sulaiman O, Hashim R, Ahmad A . Adsorption of methylene blue on low-cost adsorbents: a review. J Hazard Mater. 2010; 177(1-3):70-80. DOI: 10.1016/j.jhazmat.2009.12.047. View

15.

Besse J, Latour J, Garric J . Anticancer drugs in surface waters: what can we say about the occurrence and environmental significance of cytotoxic, cytostatic and endocrine therapy drugs?. Environ Int. 2012; 39(1):73-86. DOI: 10.1016/j.envint.2011.10.002. View

16.

Lee H, Jang Y, Choi Y, Kim M, Lee J, Lee H . Biotechnological procedures to select white rot fungi for the degradation of PAHs. J Microbiol Methods. 2013; 97:56-62. DOI: 10.1016/j.mimet.2013.12.007. View

17.

Lucas D, Castellet-Rovira F, Villagrasa M, Badia-Fabregat M, Barcelo D, Vicent T . The role of sorption processes in the removal of pharmaceuticals by fungal treatment of wastewater. Sci Total Environ. 2017; 610-611:1147-1153. DOI: 10.1016/j.scitotenv.2017.08.118. View

18.

Tomaszewski M, Cema G, Ziembinska-Buczynska A . Influence of temperature and pH on the anammox process: A review and meta-analysis. Chemosphere. 2017; 182:203-214. DOI: 10.1016/j.chemosphere.2017.05.003. View

19.

Jelic A, Cruz-Morato C, Marco-Urrea E, Sarra M, Perez S, Vicent T . Degradation of carbamazepine by Trametes versicolor in an air pulsed fluidized bed bioreactor and identification of intermediates. Water Res. 2011; 46(4):955-64. DOI: 10.1016/j.watres.2011.11.063. View

20.

Jureczko M, Przystas W, Krawczyk T, Gonciarz W, Rudnicka K . White-rot fungi-mediated biodegradation of cytostatic drugs - bleomycin and vincristine. J Hazard Mater. 2020; 407:124632. DOI: 10.1016/j.jhazmat.2020.124632. View