Metabolic Regulation in the Immune Response to Cancer

Overview

Journal Cancer Commun (Lond)

Publisher Wiley

Specialty Oncology

Date 2021 Jun 19

PMID 34145990

Citations 22

Authors

Qi Wu

Xin Yu

Juanjuan Li

Shengrong Sun

Yi Tu

Affiliations

Soon will be listed here.

Abstract

Metabolic reprogramming in tumor-immune interactions is emerging as a key factor affecting pro-inflammatory carcinogenic effects and anticancer immune responses. Therefore, dysregulated metabolites and their regulators affect both cancer progression and therapeutic response. Here, we describe the molecular mechanisms through which microenvironmental, systemic, and microbial metabolites potentially influence the host immune response to mediate malignant progression and therapeutic intervention. We summarized the primary interplaying factors that constitute metabolism, immunological reactions, and cancer with a focus on mechanistic aspects. Finally, we discussed the possibility of metabolic interventions at multiple levels to enhance the efficacy of immunotherapeutic and conventional approaches for future anticancer treatments.

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