Prenatal Sonographic and Cytogenetic/molecular Findings of 22q11.2 Microdeletion Syndrome in 48 Confirmed Cases in a Single Tertiary Center

Overview

Journal Arch Gynecol Obstet

Specialty Gynecology & Obstetrics

Date 2021 Jun 19

PMID 34145474

Citations 3

Authors

Tugba Sarac Sivrikoz

Seher Basaran

Recep Has

Birsen Karaman

Ibrahim Halil Kalelioglu

Melike Kirgiz

Umut Altunoglu

Atil Yuksel

Affiliations

Soon will be listed here.

Abstract

Purpose: We aimed to present the fetal ultrasound, cytogenetic/molecular testing and postmortem or postnatal clinical findings of cases with 22q11.2DS diagnosed prenatally.

Materials And Methods: A retrospective medical record review of 48 prenatal cases diagnosed with 22q11.2DS were evaluated in our institution. Detailed ultrasound examination was performed on all fetuses. Postmortem and postnatal examinations were evaluated. The microdeletions were detected by karyotyping or microarray, then confirmed by FISH. Descriptive statistical analysis was performed.

Results: Demographic data of 48 prenatal cases including 46 singletons and 1 dichorionic diamniotic twin pregnancy were evaluated. The most common extracardiac anomaly was skeletal system anomalies (25%), in which PEV was the most frequent one (20.8%). Polyhydramnios rate was detected as 31%, in 6.6% as an isolated finding. Microdeletion has been detected by karyotyping in 13 cases (13/47, 27.7%) (including 2 unbalanced translocations), by FISH in 28 cases (28/48, 58.3%), by microarray/a-CGH testing in 7 cases. Microarray analysis showed that in one case with unbalanced translocation had two consecutive deletions; one was proximal and other one distal to critical region and not encompassing TBX1 gene but CRKL and LZTR1 genes.

Conclusion: The current study demonstrates the whole spectrum of atypical phenotypic and genotypic variations of 22q11.2DS in the largest prenatal case series reported to date. Therefore, differential diagnosis should be considered not solely in CHD, but also in the presence of isolated clubfeet and polyhydramnios. Establishing the diagnosis in the prenatal period may allow a postnatal multidisciplinary approach, as well as affect the actual prevalence of the disease.

Citing Articles

Prenatal cardiac findings and 22q11.2 deletion syndrome: Fetal detection and evaluation.

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Clinical Course and Outcome of Prenatally Detected 22q11.2 Deletion Syndrome-A Retrospective Analysis.

Paternostro C, Springer S, Kasprian G, Yerlikaya-Schatten G, Reischer T Diagnostics (Basel). 2023; 13(13).

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Prenatal Screening and Diagnostic Considerations for 22q11.2 Microdeletions.

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Prenatal phenotyping: A community effort to enhance the Human Phenotype Ontology.

Dhombres F, Morgan P, Chaudhari B, Filges I, Sparks T, Lapunzina P Am J Med Genet C Semin Med Genet. 2022; 190(2):231-242.

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