HGF/c-MET Pathway in Cancer: from Molecular Characterization to Clinical Evidence

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 2021 Jun 19

PMID 34145400

Citations 70

Authors

Jianjiang Fu

Xiaorui Su

Zhihua Li

Ling Deng

Xiawei Liu

Xuancheng Feng

Juan Peng

Affiliations

Soon will be listed here.

Abstract

This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor (HGF) /mesenchymal-epithelial transition factor (c-MET)) signaling pathway in cancers. First, we generalize the compelling influence of HGF/c-MET pathway on multiple cellular processes. Then, we present the genomic characterization of HGF/c-MET pathway in carcinogenesis. Furthermore, we extensively illustrate the malignant biological behaviors of HGF/c-MET pathway in cancers, in which hyperactive HGF/c-MET signaling is considered as a hallmark. In addition, we investigate the current clinical trials of HGF/c-MET-targeted therapy in cancers. We find that although HGF/c-MET-targeted therapy has led to breakthroughs in certain cancers, monotherapy of targeting HGF/c-MET has failed to demonstrate significant clinical efficacy in most cancers. With the advantage of the combinations of HGF/c-MET-targeted therapy, the exploration of more options of combinational targeted therapy in cancers may be the major challenge in the future.

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