D-Dimer: A Potential Solution to Problems of Cancer Screening, Surveillance, and Prognosis Assessment

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2021 Jun 18

PMID 34141508

Citations 9

Authors

Nabeel A Siddiqui

Mushrin Malik

Ransirini Wijeratne Fernando

Archana Sreekantan Nair

Janan Illango

Rajvi Gor

Pousette Hamid

Affiliations

Soon will be listed here.

Abstract

Research has established a direct link between the plasma level of D-dimer and underlying malignancy. D-dimer has a strong association with the detection and prognosis of several cancers. For these reasons, this literature review aimed to evaluate the usefulness of elevated D-dimer levels in the initial screening of cancer, cancer recurrence surveillance, and for use as a cancer prognostic tool. A search of PubMed up to February 1, 2021, was carried out by reviewers. This literature review includes studies investigating the relationship between pretreatment plasma D-dimer levels and cancer. From the findings, pretreatment D-dimer levels can assist with cancer screening and prognosis assessment. Pretreatment plasma D-dimer levels can function as an effective cancer recurrence control. Elevated pre-treatment plasma D-dimer concentration is valuable in facilitating cancer screening, predicting an augmented risk of cancer recurrence, and anticipating a worse cancer prognosis.

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