A Mini-review of the Rodent Models for Alcoholic Liver Disease: Shortcomings, Application, and Future Prospects

Overview

Journal Toxicol Res (Camb)

Publisher Oxford University Press

Date 2021 Jun 18

PMID 34141166

Citations 5

Authors

Shi-Xuan Liu

Yan-Chao Du

Tao Zeng

Affiliations

Soon will be listed here.

Abstract

Rodents are the most common models in studies of alcoholic liver disease (ALD). Although several rodents ALD models have been established and multiple mechanisms have been elucidated based on them, these models have some non-negligible shortcomings, specifically only inducing early stage (mainly steatosis, slight to moderate steatohepatitis) but not the whole spectrum of human ALD. The resistance of rodents to advanced ALD has been suggested to be due to the physiological differences between rodents and human beings. Previous studies have reported significant interstrain differences in the susceptibility to ethanol-induced liver injury and in the manifestation of ALD (such as different alteration of lipid profiles). Therefore, it would be interesting to characterize the manifestation of ethanol-induced liver damage in various rodents, which may provide a recommendation to investigators of ALD. Furthermore, more severe ALD models need to be established for the study of serious ALD forms, which may be achieved by using genetic modified rodents.

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References

Gao B, Xu M, Bertola A, Wang H, Zhou Z, Liangpunsakul S . Animal Models of Alcoholic Liver Disease: Pathogenesis and Clinical Relevance. Gene Expr. 2017; 17(3):173-186. PMC: 5500917. DOI: 10.3727/105221617X695519. View

Loft S, Olesen K, Dossing M . Increased susceptibility to liver disease in relation to alcohol consumption in women. Scand J Gastroenterol. 1987; 22(10):1251-6. DOI: 10.3109/00365528708996472. View

Sheron N . Alcohol and liver disease in Europe--Simple measures have the potential to prevent tens of thousands of premature deaths. J Hepatol. 2015; 64(4):957-67. DOI: 10.1016/j.jhep.2015.11.006. View

Larosche I, Choumar A, Fromenty B, Letteron P, Abbey-Toby A, Van Remmen H . Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates. Toxicol Appl Pharmacol. 2008; 234(3):326-38. DOI: 10.1016/j.taap.2008.11.004. View

Huang L, Wan J, Wang B, He C, Ma H, Li T . Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. Prostaglandins Leukot Essent Fatty Acids. 2013; 88(5):347-53. DOI: 10.1016/j.plefa.2013.02.002. View

Lu Y, Cederbaum A . CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction. Genes Nutr. 2009; 5(2):149-67. PMC: 2885169. DOI: 10.1007/s12263-009-0150-5. View

Xiong Y, Yang Y, Yang J, Chai H, Li Y, Yang J . Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanol-induced liver steatosis in mice. Toxicology. 2010; 276(1):64-72. DOI: 10.1016/j.tox.2010.07.007. View

Cederbaum A . Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity. Dig Dis. 2011; 28(6):802-11. PMC: 3211519. DOI: 10.1159/000324289. View

Ganne-Carrie N, Nahon P . Hepatocellular carcinoma in the setting of alcohol-related liver disease. J Hepatol. 2019; 70(2):284-293. DOI: 10.1016/j.jhep.2018.10.008. View

10.

Gao B, Bataller R . Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 2011; 141(5):1572-85. PMC: 3214974. DOI: 10.1053/j.gastro.2011.09.002. View

11.

Bloomer S, Broadhurst K, Maleah Mathahs M, Brown K . Effects of long-term ethanol ingestion on hepatic iron metabolism in two mouse strains. Clin Exp Pharmacol Physiol. 2020; 48(4):534-542. DOI: 10.1111/1440-1681.13445. View

12.

Koop D, Klopfenstein B, Iimuro Y, Thurman R . Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Mol Pharmacol. 1997; 51(6):944-50. DOI: 10.1124/mol.51.6.944. View

13.

Kanbagli O, Balkan J, Aykac-Toker G, Uysal M . Hepatic mitochondrial prooxidant and antioxidant status in ethanol-induced liver injury in rats. Biol Pharm Bull. 2002; 25(11):1482-4. DOI: 10.1248/bpb.25.1482. View

14.

Yamashina S, Wheeler M, Rusyn I, Ikejima K, Sato N, Thurman R . Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase. Biochem Biophys Res Commun. 2000; 277(3):686-90. DOI: 10.1006/bbrc.2000.3738. View

15.

Keegan A, Martini R, Batey R . Ethanol-related liver injury in the rat: a model of steatosis, inflammation and pericentral fibrosis. J Hepatol. 1995; 23(5):591-600. DOI: 10.1016/0168-8278(95)80067-0. View

16.

BEST C, HARTROFT W . Liver damage produced by feeding alcohol or sugar and its prevention by choline. Br Med J. 1949; 2(4635):1002-6, pl. PMC: 2051633. DOI: 10.1136/bmj.2.4635.1001. View

17.

Yoneyama N, Crabbe J, Ford M, Murillo A, Finn D . Voluntary ethanol consumption in 22 inbred mouse strains. Alcohol. 2008; 42(3):149-60. PMC: 2396347. DOI: 10.1016/j.alcohol.2007.12.006. View

18.

Zhang X, Meng F, Wang Y, Liu S, Zeng T . Transformed ALDH2 hepatocytes by ethanol could serve as a useful tool for studying alcoholic hepatocarcinogenesis. Med Hypotheses. 2020; 146:110366. DOI: 10.1016/j.mehy.2020.110366. View

19.

You M, Fischer M, Deeg M, Crabb D . Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem. 2002; 277(32):29342-7. DOI: 10.1074/jbc.M202411200. View

20.

Eagon P . Alcoholic liver injury: influence of gender and hormones. World J Gastroenterol. 2010; 16(11):1377-84. PMC: 2842530. DOI: 10.3748/wjg.v16.i11.1377. View