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KDF1, a Novel Tumor Suppressor in Clear Cell Renal Cell Carcinoma

Overview
Journal Front Oncol
Specialty Oncology
Date 2021 Jun 17
PMID 34136411
Citations 8
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Abstract

KDF1 has been identified as a key regulator of epidermal proliferation and differentiation, but it is unknown whether KDF1 is involved in the pathogenesis of malignancy. No study has reported the expression and function of KDF1 in renal cancer. To explore the pathologic significance of KDF1 in clear cell renal cell carcinoma (ccRCC), the expression level of KDF1 protein in the tumor tissue of ccRCC patients was examined by immunohistochemistry and Western blot while the expression level of KDF1 mRNA was analyzed by using the data from TCGA database. In vitro cell experiments and allogeneic tumor transplantation tests were performed to determine the effects of altered KDF1 expression on the phenotype of ccRCC cells. Both the KDF1 mRNA and protein were found to be decreasingly expressed in the tumor tissue of ccRCC patients when compared with the adjacent non-tumor control tissue. The expression level of KDF1 in the tumor tissue was found to correlate negatively with the tumor grade. Patients with higher KDF1 in the tumor tissue were found to have longer overall survival and disease-specific survival time. KDF1 was shown to be an independent factor influencing the disease-specific survival of the ccRCC patients. Overexpression of KDF1 was found to inhibit the proliferation, migration and invasion of ccRCC cells, which could be reversed by decreasing the expression of KDF1 again. ccRCC cells with KDF1 overexpression were found to produce smaller transgrafted tumors. These results support the idea that KDF1 is involved in ccRCC and may function as a tumor suppressor.

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References
1.
. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015; 517(7536):576-82. PMC: 4311405. DOI: 10.1038/nature14129. View

2.
Quan X, Hawk N, Chen W, Coupar J, Lee S, Petersen D . Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133 Skin Cancer Stem Cells. Mol Cancer Ther. 2018; 17(9):2034-2048. PMC: 6461743. DOI: 10.1158/1535-7163.MCT-17-0421. View

3.
Truong A, Kretz M, Ridky T, Kimmel R, Khavari P . p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev. 2006; 20(22):3185-97. PMC: 1635152. DOI: 10.1101/gad.1463206. View

4.
Uhlen M, Bjorling E, Agaton C, Szigyarto C, Amini B, Andersen E . A human protein atlas for normal and cancer tissues based on antibody proteomics. Mol Cell Proteomics. 2005; 4(12):1920-32. DOI: 10.1074/mcp.M500279-MCP200. View

5.
Ta N, Huang X, Zheng K, Zhang Y, Gao Y, Deng L . miRNA-1290 Promotes Aggressiveness in Pancreatic Ductal Adenocarcinoma by Targeting IKK1. Cell Physiol Biochem. 2018; 51(2):711-728. DOI: 10.1159/000495328. View