[Effect of Fatty Acid Synthase Gene Silencing on Lipid Metabolism and Biological Behaviors of Human Hepatoblastoma HepG2 Cells]

Overview

Journal Nan Fang Yi Ke Da Xue Xue Bao

Specialty General Medicine

Date 2021 Jun 17

PMID 34134963

Citations 1

Authors

H Huang

Y Wei

J Wang

F Ran

Q Chen

Affiliations

Soon will be listed here.

Abstract

Objective: FASN gene silencing inhibits proliferation and migration and promotes apoptosis of HepG2 cells possibly by suppressing lipid synthesis in the cells.

Citing Articles

Landscape of the oncogenic role of fatty acid synthase in human tumors.

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PMID: 34879004 PMC: 8714155. DOI: 10.18632/aging.203730.

References

Zaytseva Y, Elliott V, Rychahou P, Mustain W, Kim J, Valentino J . Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. Carcinogenesis. 2014; 35(6):1341-51. PMC: 4043242. DOI: 10.1093/carcin/bgu042. View

Liu Y, Song J, Liu Y, Zhou Z, Wang X . Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2. J Exp Clin Cancer Res. 2020; 39(1):101. PMC: 7268652. DOI: 10.1186/s13046-020-01598-8. View

Bian Y, Yu Y, Wang S, Li L . Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer. Biochem Biophys Res Commun. 2015; 463(4):612-7. DOI: 10.1016/j.bbrc.2015.05.108. View

Gu L, Zhu Y, Lin X, Tan X, Lu B, Li Y . Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis. Oncogene. 2020; 39(11):2437-2449. DOI: 10.1038/s41388-020-1156-0. View

Xu S, Chen T, Dong L, Li T, Xue H, Gao B . Fatty acid synthase promotes breast cancer metastasis by mediating changes in fatty acid metabolism. Oncol Lett. 2020; 21(1):27. PMC: 7681230. DOI: 10.3892/ol.2020.12288. View

Doustimotlagh A, Kokhdan E, Vakilpour H, Khalvati B, Barmak M, Sadeghi H . Protective effect of Nasturtium officinale R. Br and quercetin against cyclophosphamide-induced hepatotoxicity in rats. Mol Biol Rep. 2020; 47(7):5001-5012. DOI: 10.1007/s11033-020-05556-7. View

Beck A, Trippel F, Wagner A, Joppien S, Felle M, Vokuhl C . Overexpression of promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma. Clin Epigenetics. 2018; 10:27. PMC: 5833129. DOI: 10.1186/s13148-018-0462-7. View

Katzenstein H, Langham M, Malogolowkin M, Krailo M, Towbin A, McCarville M . Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children's Oncology Group, multicentre, phase 3 trial. Lancet Oncol. 2019; 20(5):719-727. PMC: 6499702. DOI: 10.1016/S1470-2045(18)30895-7. View

Zaidi N, Lupien L, Kuemmerle N, Kinlaw W, Swinnen J, Smans K . Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. Prog Lipid Res. 2013; 52(4):585-9. PMC: 4002264. DOI: 10.1016/j.plipres.2013.08.005. View

10.

Najafi M, Tavakol S, Zarrabi A, Ashrafizadeh M . Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: a review. Arch Physiol Biochem. 2020; 128(6):1438-1452. DOI: 10.1080/13813455.2020.1773864. View

11.

Cui Y, Xing P, Wang Y, Liu M, Qiu L, Ying G . NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition. Oncotarget. 2017; 8(20):32576-32585. PMC: 5464810. DOI: 10.18632/oncotarget.15936. View

12.

Fujii K, Luo Y, Fujiwara-Tani R, Kishi S, He S, Yang S . Pro-metastatic intracellular signaling of the elaidic trans fatty acid. Int J Oncol. 2016; 50(1):85-92. DOI: 10.3892/ijo.2016.3797. View

13.

Beyea J, Lau C, Cooke B, Hall S, Nathan P, Gupta S . Long-Term Incidence and Predictors of Significant Hearing Loss Requiring Hearing Assistive Devices Among Childhood Cancer Survivors: A Population-Based Study. J Clin Oncol. 2020; 38(23):2639-2646. DOI: 10.1200/JCO.19.03166. View

14.

Tay S, Foster J, Heczey A, Sitton M . Pediatric Oncology Patients With Vincristine-Induced Recurrent Laryngeal Nerve Palsy: Two Case Reports and a Brief Review of Literature. Ear Nose Throat J. 2020; 100(10):NP459-NP463. DOI: 10.1177/0145561320924868. View

15.

Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R . Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells. Pathobiology. 2016; 84(3):144-151. DOI: 10.1159/000449205. View

16.

Gong J, Shen S, Yang Y, Qin S, Huang L, Zhang H . Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1α/IGFBP1 pathway. Int J Oncol. 2017; 50(3):883-892. DOI: 10.3892/ijo.2017.3867. View

17.

Shen M, Tsai Y, Zhu R, Keng P, Chen Y, Chen Y . FASN-TGF-β1-PD-L1 axis contributes to the development of resistance to NK cell cytotoxicity of cisplatin-resistant lung cancer cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1863(3):313-322. DOI: 10.1016/j.bbalip.2017.12.012. View

18.

Polonio-Alcala E, Palomeras S, Torres-Oteros D, Relat J, Planas M, Feliu L . Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models. Cancers (Basel). 2020; 12(5). PMC: 7281741. DOI: 10.3390/cancers12051283. View

19.

Menendez J, Lupu R . Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells. Curr Opin Clin Nutr Metab Care. 2006; 9(4):346-57. DOI: 10.1097/01.mco.0000232893.21050.15. View

20.

Wang H, Xi Q, Wu G . Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway. Cancer Med. 2016; 5(7):1599-606. PMC: 4864275. DOI: 10.1002/cam4.711. View