Gastrointestinal Symptoms in HIV-positive Kidney Transplant Candidates and Recipients from an HIV-positive Donor

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jun 16

PMID 34131245

Authors

C J Martin

F J Veldman

D Labadarios

Z Ebrahim

E Muller

S M Kassier

Affiliations

Soon will be listed here.

Abstract

Gastrointestinal symptoms (GIS) are common in kidney transplant candidates and recipients and may be worsened by HIV. Objective: To determine the frequency and severity of GIS in HIV-positive kidney transplant recipients from HIV-positive donors, and those waiting to receive one. A GIS rating scale (GSRS) was completed by 76 participants at baseline and at 6 months. GIS frequency was defined as having at least one symptom (GSRS > 1). Severity was indicated by the GSRS score. Transplant candidates: GIS frequency was 88.9% and 86.3% at baseline and 6 months respectively. Indigestion was the most frequent (79.6% and 66.7% at baseline and 6 months), and severe GIS (GSRS 2.3). Women reported global mean (p = 0.030) severity significantly more than men. Transplant recipients: GIS frequency was 95.2% and 76.2% at baseline and 6 months respectively. At both assessment points, indigestion occurred most frequently (85.7% and 61.9% respectively). Highest GSRS was reported for indigestion at baseline (2.33) and at 6 months (1.33). Waist circumference (WC) was positively associated with the severity of constipation GSRS. GIS are common in both groups, especially indigestions. WC in transplant recipients should be monitored.

References

Sarkio S, Halme L, Kyllonen L, Salmela K . Severe gastrointestinal complications after 1,515 adult kidney transplantations. Transpl Int. 2004; 17(9):505-10. DOI: 10.1007/s00147-004-0748-x. View

Cano A, Neil A, Kang J, Barnabas A, Eastwood J, Nelson S . Gastrointestinal symptoms in patients with end-stage renal disease undergoing treatment by hemodialysis or peritoneal dialysis. Am J Gastroenterol. 2007; 102(9):1990-7. DOI: 10.1111/j.1572-0241.2007.01321.x. View

Strid H, Simren M, Bjornsson E . Overuse of acid suppressant drugs in patients with chronic renal failure. Nephrol Dial Transplant. 2003; 18(3):570-5. DOI: 10.1093/ndt/18.3.570. View

Bunnapradist S, Neri L, Wong W, Lentine K, Burroughs T, Pinsky B . Incidence and risk factors for diarrhea following kidney transplantation and association with graft loss and mortality. Am J Kidney Dis. 2008; 51(3):478-86. DOI: 10.1053/j.ajkd.2007.11.013. View

Kawakubo H, Tanaka Y, Tsuruoka N, Hara M, Yamamoto K, Hidaka H . Upper Gastrointestinal Symptoms Are More Frequent in Female than Male Young Healthy Japanese Volunteers as Evaluated by Questionnaire. J Neurogastroenterol Motil. 2016; 22(2):248-53. PMC: 4819863. DOI: 10.5056/jnm15140. View

Laeeq S, Tasneem A, Hanif F, Hassan Luck N, Mandhwani R, Wadhva R . Upper Gastrointestinal Bleeding in Patients with End Stage Renal Disease: Causes, Characteristics and Factors Associated with Need for Endoscopic Therapeutic Intervention. J Transl Int Med. 2017; 5(2):106-111. PMC: 5506410. DOI: 10.1515/jtim-2017-0019. View

Ekberg H, Kyllonen L, Madsen S, Grave G, Solbu D, Holdaas H . Increased prevalence of gastrointestinal symptoms associated with impaired quality of life in renal transplant recipients. Transplantation. 2007; 83(3):282-9. DOI: 10.1097/01.tp.0000251923.14697.f5. View

Zhang J, Huang C, Li Y, Chen J, Shen F, Yao Q . Health-related quality of life in dialysis patients with constipation: a cross-sectional study. Patient Prefer Adherence. 2013; 7:589-94. PMC: 3693922. DOI: 10.2147/PPA.S45471. View

Mayer E, Naliboff B, Lee O, Munakata J, Chang L . Review article: gender-related differences in functional gastrointestinal disorders. Aliment Pharmacol Ther. 1999; 13 Suppl 2:65-9. DOI: 10.1046/j.1365-2036.1999.00008.x. View

10.

Monkemuller K, Call S, Lazenby A, Wilcox C . Declining prevalence of opportunistic gastrointestinal disease in the era of combination antiretroviral therapy. Am J Gastroenterol. 2000; 95(2):457-62. DOI: 10.1111/j.1572-0241.2000.01768.x. View

11.

Dong R, Guo Z . Gastrointestinal symptoms in patients undergoing peritoneal dialysis: multivariate analysis of correlated factors. World J Gastroenterol. 2010; 16(22):2812-7. PMC: 2883139. DOI: 10.3748/wjg.v16.i22.2812. View

12.

Kosmadakis G, Albaret J, Da Costa Correia E, Somda F, Aguilera D . Gastrointestinal Disorders in Peritoneal Dialysis Patients. Am J Nephrol. 2018; 48(5):319-325. DOI: 10.1159/000494145. View

13.

Takahashi Y, Nagata N, Shimbo T, Nishijima T, Watanabe K, Aoki T . Upper Gastrointestinal Symptoms Predictive of Candida Esophagitis and Erosive Esophagitis in HIV and Non-HIV Patients: An Endoscopy-Based Cross-Sectional Study of 6011 Patients. Medicine (Baltimore). 2015; 94(47):e2138. PMC: 5059007. DOI: 10.1097/MD.0000000000002138. View

14.

Thomas R, Panackal C, John M, Joshi H, Mathai S, Kattickaran J . Gastrointestinal complications in patients with chronic kidney disease--a 5-year retrospective study from a tertiary referral center. Ren Fail. 2012; 35(1):49-55. DOI: 10.3109/0886022X.2012.731998. View

15.

Chang P, Friedenberg F . Obesity and GERD. Gastroenterol Clin North Am. 2014; 43(1):161-73. PMC: 3920303. DOI: 10.1016/j.gtc.2013.11.009. View

16.

Thompson C, Gay C, Kashuba A . HIV Persistence in Gut-Associated Lymphoid Tissues: Pharmacological Challenges and Opportunities. AIDS Res Hum Retroviruses. 2017; 33(6):513-523. PMC: 5467125. DOI: 10.1089/AID.2016.0253. View

17.

Napthali K, Koloski N, Walker M, Talley N . Women and functional dyspepsia. Womens Health (Lond). 2016; 12(2):241-50. PMC: 5375052. DOI: 10.2217/whe.15.88. View

18.

Kim K, Lee B . Central Obesity as a Risk Factor for Non-Erosive Reflux Disease. Yonsei Med J. 2017; 58(4):743-748. PMC: 5447104. DOI: 10.3349/ymj.2017.58.4.743. View

19.

Daniels G, Robinson J, Walker C, Pennings J, Anderson S . Gastrointestinal Symptoms among African Americans Undergoing Hemodialysis. Nephrol Nurs J. 2016; 42(6):539-48. View

20.

Ponticelli C, Passerini P . Gastrointestinal complications in renal transplant recipients. Transpl Int. 2005; 18(6):643-50. DOI: 10.1111/j.1432-2277.2005.00134.x. View