Association of Circulating Omega 3, 6 and 9 Fatty Acids with Gestational Diabetes Mellitus: a Systematic Review

Overview

Journal BMC Endocr Disord

Publisher Biomed Central

Specialty Endocrinology

Date 2021 Jun 16

PMID 34130655

Citations 8

Authors

Shaghayegh Hosseinkhani

Hojat Dehghanbanadaki

Hossein Aazami

Parvin Pasalar

Mojgan Asadi

Farideh Razi

Affiliations

Soon will be listed here.

Abstract

Background: Gestational diabetes mellitus (GDM) is associated with increased risks of disease for mother and child during pregnancy and after that. Early diagnosis of GDM would promote both maternal and fetal health. Metabolomics can simplify and develop our understanding of the etiology, manifestation, or pathophysiology of the disease. This systematic review investigates the association of circulating omega 3, 6, and 9 fatty acids with GDM.

Methods: We conducted a systematic search of PubMed, Scopus, Web of Science, and EMBASE databases up to May 8, 2020, using the key term combinations of all types of omega fatty acids with gestational diabetes mellitus. Additional articles were identified through searching the reference lists of included studies.

Results: This systematic review included 15 articles. Five were cohort studies, four included nested case-control studies and four were case-control studies. The results of this study demonstrate an increasing trend in the amount of oleic acid and palmitoleic acid in the second trimester and an increase in decosahexanoic acid in the third trimester of GDM mothers. The changes in other fatty acids of interest are either not significant or if significant, their results are inconsistent with the other existing articles.

Conclusions: Omega fatty acids, as potential biomarkers, are considered to be associated with GDM risk and thus provide useful information regarding the prevention and early diagnosis of GDM. Moreover, existing metabolomic studies on GDM are shown to provide conflicting results about metabolite profile characteristics. This systematic review was registered at PROSPERO ( www.crd.york.ac.uk/PROSPERO ) as CRD42020196122.

Citing Articles

Microbiome-derived metabolites in early to mid-pregnancy and risk of gestational diabetes: a metabolome-wide association study.

Susarla S, Fiehn O, Thiele I, Ngo A, Barupal D, Chehab R BMC Med. 2024; 22(1):449.

PMID: 39394552 PMC: 11470649. DOI: 10.1186/s12916-024-03606-6.

Omega-3 fatty acids prevent gestational diabetes mellitus via modulation of lipid metabolism.

Zhang X, Li F, Yang B, Zhang W, Wang Y Open Life Sci. 2024; 19(1):20220928.

PMID: 39119479 PMC: 11306960. DOI: 10.1515/biol-2022-0928.

Protocol for a randomized placebo-controlled clinical trial using pure palmitoleic acid to ameliorate insulin resistance and lipogenesis in overweight and obese subjects with prediabetes.

Cetin E, Pedersen B, Porter L, Adler G, Burak M Front Endocrinol (Lausanne). 2024; 14:1306528.

PMID: 38313838 PMC: 10835623. DOI: 10.3389/fendo.2023.1306528.

Metabolic drivers of dysglycemia in pregnancy: ethnic-specific GWAS of 146 metabolites and 1-sample Mendelian randomization analyses in a UK multi-ethnic birth cohort.

Fuller H, Iles M, Moore J, Zulyniak M Front Endocrinol (Lausanne). 2023; 14:1157416.

PMID: 37255970 PMC: 10225646. DOI: 10.3389/fendo.2023.1157416.

Diagnostic accuracy of circular RNA for diabetes Mellitus: a systematic review and diagnostic Meta-analysis.

Dehghanbanadaki H, Asili P, Ghadery A, Mirahmad M, Dehnavi A, Parsaei A BMC Med Genomics. 2023; 16(1):48.

PMID: 36890575 PMC: 9993609. DOI: 10.1186/s12920-023-01476-0.

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