Cucurbit[8]uril-based Supramolecular Hydrogels for Biomedical Applications

Overview

Journal RSC Med Chem

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2021 Jun 14

PMID 34124671

Citations 3

Authors

Zeyu Wang

Mingju Shui

Ian W Wyman

Qing-Wen Zhang

Ruibing Wang

Affiliations

Soon will be listed here.

Abstract

As a member of the cucurbit[]uril family (where denotes the number of glycoluril units), cucurbit[8]uril (CB[8]) possesses a large cavity volume and is able to accommodate two guests simultaneously. Therefore, CB[8] has been adapted as a dynamic noncovalent crosslinker to form various supramolecular hydrogels. These CB[8]-based hydrogels have been investigated for various biomedical applications due to their good biocompatibility and dynamic properties afforded by host-guest interactions. In this review, we summarize the hydrogels that have been dynamically fabricated supramolecular crosslinking of polymers by CB[8] reported during the past decade, and discuss their design principles, innovative applications in biomedical science and their future prospects.

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