Synthesis of Oxalamides by Acceptorless Dehydrogenative Coupling of Ethylene Glycol and Amines and the Reverse Hydrogenation Catalyzed by Ruthenium

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2021 Jun 14

PMID 34123004

Citations 1

Authors

You-Quan Zou

Quan-Quan Zhou

Yael Diskin-Posner

Yehoshoa Ben-David

David Milstein

Affiliations

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Abstract

A sustainable, new synthesis of oxalamides, by acceptorless dehydrogenative coupling of ethylene glycol with amines, generating H, homogeneously catalyzed by a ruthenium pincer complex, is presented. The reverse hydrogenation reaction is also accomplished using the same catalyst. A plausible reaction mechanism is proposed based on stoichiometric reactions, NMR studies, X-ray crystallography as well as observation of plausible intermediates.

Citing Articles

Acceptorless dehydrogenative synthesis of primary amides from alcohols and ammonia.

Luo J, Zhou Q, Montag M, Ben-David Y, Milstein D Chem Sci. 2022; 13(13):3894-3901.

PMID: 35432908 PMC: 8966752. DOI: 10.1039/d1sc07102e.

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