Acquired Hemophilia A Presenting with Infectious Aortic Aneurysms Due to an Underlying Helicobacter Cinaedi Infection

Overview

Journal Intern Med

Specialty General Medicine

Date 2021 Jun 14

PMID 34121015

Citations 1

Authors

Anna Matsuoka

Yuya Sasaki

Ai Kubodera

Kiyohito Hayashi

Ryo Shimizu

Akira Toriihara

Akira Nakamura

Keiichi Furukawa

Hiroaki Tanaka

Affiliations

Soon will be listed here.

Abstract

Acquired hemophilia A (AHA) is a bleeding disorder caused by the acquired appearance of inhibitor for factor VIII. Approximately half of all patients with AHA have some type of underlying disease. We herein report the case of a 72-year-old Japanese man with AHA who presented with infectious aortic aneurysms due to an underlying Helicobacter cinaedi infection. To our knowledge, this is the first report of AHA triggered by a bacterial infection; however, there may be similar cases that remain undiagnosed because this pathogen is difficult to identify. Clinicians should consider the possibility of H. cinaedi as a causative pathogen in patients presenting with a fever of unknown origin.

Citing Articles

bacterium association with atherosclerosis and other diseases.

Voronina A, Arapidi G Front Microbiol. 2024; 15:1371717.

PMID: 38650874 PMC: 11033375. DOI: 10.3389/fmicb.2024.1371717.

References

Suematsu Y, Morizumi S, Okamura K, Kawata M . A rare case of axillobifemoral bypass graft infection caused by Helicobacter cinaedi. J Vasc Surg. 2013; 61(1):231-3. DOI: 10.1016/j.jvs.2013.08.048. View

Lacroix-Desmazes S, Navarrete A, Andre S, Bayry J, Kaveri S, Dasgupta S . Dynamics of factor VIII interactions determine its immunologic fate in hemophilia A. Blood. 2008; 112(2):240-9. DOI: 10.1182/blood-2008-02-124941. View

Matzinger P . Tolerance, danger, and the extended family. Annu Rev Immunol. 1994; 12:991-1045. DOI: 10.1146/annurev.iy.12.040194.005015. View

Kawamura Y, Tomida J, Morita Y, Fujii S, Okamoto T, Akaike T . Clinical and bacteriological characteristics of Helicobacter cinaedi infection. J Infect Chemother. 2014; 20(9):517-26. DOI: 10.1016/j.jiac.2014.06.007. View

Mikail N, Benali K, Dossier A, Bouleti C, Hyafil F, Le Guludec D . Additional Diagnostic Value of Combined Angio-Computed Tomography and F-Fluorodeoxyglucose Positron Emission Tomography in Infectious Aortitis. JACC Cardiovasc Imaging. 2017; 11(2 Pt 2):361-364. DOI: 10.1016/j.jcmg.2017.07.018. View

Khan S, Rahman H, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T . Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses. Sci Rep. 2014; 4:4680. PMC: 3986732. DOI: 10.1038/srep04680. View

Matsuo T, Mori N, Mizuno A, Sakurai A, Kawai F, Starkey J . Infected aortic aneurysm caused by Helicobacter cinaedi: case series and systematic review of the literature. BMC Infect Dis. 2020; 20(1):854. PMC: 7670619. DOI: 10.1186/s12879-020-05582-7. View

DElios M, Vallese F, Capitani N, Benagiano M, Bernardini M, Rossi M . The Helicobacter cinaedi antigen CAIP participates in atherosclerotic inflammation by promoting the differentiation of macrophages in foam cells. Sci Rep. 2017; 7:40515. PMC: 5225449. DOI: 10.1038/srep40515. View

Takahashi T, Yujiri T, Shinohara K, Inoue Y, Sato Y, Fujii Y . Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori-associated chronic idiopathic thrombocytopenic purpura. Br J Haematol. 2003; 124(1):91-6. DOI: 10.1046/j.1365-2141.2003.04735.x. View

10.

Nakao S, Hagiya H, Kimura K, Mitsui T, Oyama A, Hongyo K . Helicobacter cinaedi-associated Carotid Arteritis. Acta Med Okayama. 2018; 72(2):189-192. DOI: 10.18926/AMO/55861. View

11.

Yuki N, Yoshino H, Sato S, Miyatake T . Acute axonal polyneuropathy associated with anti-GM1 antibodies following Campylobacter enteritis. Neurology. 1990; 40(12):1900-2. DOI: 10.1212/wnl.40.12.1900. View

12.

Hay C, Brown S, Collins P, Keeling D, Liesner R . The diagnosis and management of factor VIII and IX inhibitors: a guideline from the United Kingdom Haemophilia Centre Doctors Organisation. Br J Haematol. 2006; 133(6):591-605. DOI: 10.1111/j.1365-2141.2006.06087.x. View

13.

Ushiki M, Koike M, Akiyama T, Watanabe S, Koyasu H, Mituhashi D . [Acquired hemophilia A with rectus abdominis muscle and intrapelvic hematomas after aortic arch replacement]. Rinsho Ketsueki. 2011; 52(1):8-13. View

14.

Araoka H, Baba M, Kimura M, Abe M, Inagawa H, Yoneyama A . Clinical characteristics of bacteremia caused by Helicobacter cinaedi and time required for blood cultures to become positive. J Clin Microbiol. 2014; 52(5):1519-22. PMC: 3993694. DOI: 10.1128/JCM.00265-14. View

15.

Khan U, Yang X, Masroor M, Aziz A, Yi H, Liu H . Surgery-associated acquired hemophilia A: a report of 2 cases and review of literature. BMC Surg. 2020; 20(1):213. PMC: 7510307. DOI: 10.1186/s12893-020-00872-y. View

16.

Gasbarrini A, Franceschi F, Tartaglione R, Landolfi R, Pola P, Gasbarrini G . Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori. Lancet. 1998; 352(9131):878. DOI: 10.1016/S0140-6736(05)60004-9. View

17.

Collins P, Baudo F, Knoebl P, Levesque H, Nemes L, Pellegrini F . Immunosuppression for acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). Blood. 2012; 120(1):47-55. PMC: 3390961. DOI: 10.1182/blood-2012-02-409185. View

18.

Khan S, Okamoto T, Enomoto K, Sakashita N, Oyama K, Fujii S . Potential association of Helicobacter cinaedi with atrial arrhythmias and atherosclerosis. Microbiol Immunol. 2012; 56(3):145-54. DOI: 10.1111/j.1348-0421.2012.00421.x. View

19.

Borg J, Guillet B, Le Cam-Duchez V, Goudemand J, Levesque H . Outcome of acquired haemophilia in France: the prospective SACHA (Surveillance des Auto antiCorps au cours de l'Hémophilie Acquise) registry. Haemophilia. 2013; 19(4):564-70. DOI: 10.1111/hae.12138. View

20.

Fennell C, Totten P, Quinn T, Patton D, Holmes K, Stamm W . Characterization of Campylobacter-like organisms isolated from homosexual men. J Infect Dis. 1984; 149(1):58-66. DOI: 10.1093/infdis/149.1.58. View