Successful Isavuconazole Salvage Therapy for a Cryptococcus Deuterogattii (AFLP6/VGII) Disseminated Infection in a European Immunocompetent Patient

Overview

Journal Mycopathologia

Specialties Microbiology
Pharmacology

Date 2021 Jun 11

PMID 34115285

Citations 3

Authors

Maria Soledad Cuetara

Juan Jose Jusdado Ruiz-Capillas

Maria Pilar Nunez-Valentin

Elena Rodriguez Garcia

Elena Garcia-Benayas

Ricardo Rojo-Amigo

Jose Carlos Rodriguez-Gallego

Ferry Hagen

Maria Francisca Colom

Affiliations

Soon will be listed here.

Abstract

Members of the Cryptococcus gattii species complex are notorious causes of cryptococcosis as they often cause severe, life-threatening infections. Here we describe a case of a severe disseminated C. deuterogattii infection in a previously healthy patient who was initially treated with amphotericin B, 5-fluorocytosine and fluconazole, which led to a good neurological response, but the infection in the lungs remained unaltered and was not completely resolved until switching the antifungal therapy to isavuconazole. The infection was likely acquired during a one-month stay at the Azores Islands, Portugal. Environmental sampling did not yield any cryptococcal isolate; therefore, the source of this apparent autochthonous case could not be determined. Molecular typing showed that the cultured C. deuterogattii isolates were closely related to the Vancouver Island outbreak-genotype.

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