Evolutionary and Ecological Drivers Shape the Emergence and Extinction of Foot-and-Mouth Disease Virus Lineages

Overview

Journal Mol Biol Evol

Publisher Oxford University Press

Specialty Biology

Date 2021 Jun 11

PMID 34115138

Citations 16

Authors

Antonello Di Nardo

Luca Ferretti

Jemma Wadsworth

Valerie Mioulet

Boris Gelman

Sharon Karniely

Alexey Scherbakov

Ghulam Ziay

Fuat Ozyoruk

Unal Parlak

Pelin Tuncer-Goktuna

Reza Hassanzadeh

Mehdi Khalaj

Seyed Mohsen Dastoor

Darab Abdollahi

Ehtisham-Ul-Haq Khan

Muhammad Afzal

Manzoor Hussain

Nick J Knowles

Donald P King

Affiliations

Soon will be listed here.

Abstract

Livestock farming across the world is constantly threatened by the evolutionary turnover of foot-and-mouth disease virus (FMDV) strains in endemic systems, the underlying dynamics of which remain to be elucidated. Here, we map the eco-evolutionary landscape of cocirculating FMDV lineages within an important endemic virus pool encompassing Western, Central, and parts of Southern Asia, reconstructing the evolutionary history and spatial dynamics over the last 20 years that shape the current epidemiological situation. We demonstrate that new FMDV variants periodically emerge from Southern Asia, precipitating waves of virus incursions that systematically travel in a westerly direction. We evidence how metapopulation dynamics drive the emergence and extinction of spatially structured virus populations, and how transmission in different host species regulates the evolutionary space of virus serotypes. Our work provides the first integrative framework that defines coevolutionary signatures of FMDV in regional contexts to help understand the complex interplay between virus phenotypes, host characteristics, and key epidemiological determinants of transmission that drive FMDV evolution in endemic settings.

Citing Articles

The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013-2014 Has Significant Implications for the Epidemiology of the Virus in the Region.

Nikiforov V, Noskov S, Sprygin A, Alhussen M, Krylova A, Erofeeva T Viruses. 2025; 17(1.

PMID: 39861797 PMC: 11769220. DOI: 10.3390/v17010008.

A broadly reactive ultralong bovine antibody that can determine the integrity of foot-and-mouth disease virus capsids.

Clarke J, Duyvesteyn H, Perez-Martin E, Latisenko U, Porta C, Humphreys K J Gen Virol. 2024; 105(10).

PMID: 39422666 PMC: 11488517. DOI: 10.1099/jgv.0.002032.

Why Foot-and-Mouth Disease-Free with Vaccination Should Be Equivalent to Foot-and-Mouth Disease-Free without Vaccination.

Moura P, Kihm U, Schudel A, Bergmann I, Buholzer P Vet Sci. 2024; 11(6).

PMID: 38922028 PMC: 11209047. DOI: 10.3390/vetsci11060281.

Phylodynamic analysis of foot-and-mouth disease virus evolution in Mar Chiquita, Argentina.

Calderon L, Cabanne G, Marcos A, Novo S, Torres C, Perez A Arch Virol. 2024; 169(5):101.

PMID: 38630189 DOI: 10.1007/s00705-024-06028-0.

The multiple roles of viral 3D protein in picornavirus infections.

Nie Z, Zhai F, Zhang H, Zheng H, Pei J Virulence. 2024; 15(1):2333562.

PMID: 38622757 PMC: 11020597. DOI: 10.1080/21505594.2024.2333562.

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