Run for Your Life: Can Exercise Be Used to Effectively Target GLUT4 in Diabetic Cardiac Disease?

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2021 Jun 11

PMID 34113491

Citations 3

Authors

Peter R T Bowman

Godfrey L Smith

Gwyn W Gould

Affiliations

Soon will be listed here.

Abstract

The global incidence, associated mortality rates and economic burden of diabetes are now such that it is considered one of the most pressing worldwide public health challenges. Considerable research is now devoted to better understanding the mechanisms underlying the onset and progression of this disease, with an ultimate aim of improving the array of available preventive and therapeutic interventions. One area of particular unmet clinical need is the significantly elevated rate of cardiomyopathy in diabetic patients, which in part contributes to cardiovascular disease being the primary cause of premature death in this population. This review will first consider the role of metabolism and more specifically the insulin sensitive glucose transporter GLUT4 in diabetic cardiac disease, before addressing how we may use exercise to intervene in order to beneficially impact key functional clinical outcomes.

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