IgA Deficiency and Membranoproliferative Glomerulonephritis: A Case Report

Overview

Journal Int Med Case Rep J

Publisher Dove Medical Press

Specialty General Medicine

Date 2021 Jun 11

PMID 34113180

Authors

Alessandro Pezzutto

Vittorio Sirolli

Lorenzo Di Liberato

Manrico Morroni

Mario Bonomini

Affiliations

Soon will be listed here.

Abstract

Background: Immunoglobulin A deficiency (IgAD) is the most common form of primary immunodeficiency in western countries. It can be associated with the development of autoimmune diseases both in adults and in children even though the exact pathophysiology is not fully defined.

Case Presentation: We report here a case of a young patient who developed nephrotic syndrome secondary to membranoproliferative glomerulonephritis associated with the incidental finding of IgAD. We began corticosteroid therapy and angiotensin-converting enzyme inhibitor, and we observed partial remission of the nephrotic syndrome after about nine months; nonetheless, in the following follow-up visits, a progressive decline of renal function was found.

Conclusion: Our case extends the spectrum of hitherto described glomerulonephritides associated with IgAD which were described until now.

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