Subcellular Changes and Apoptosis Induced by Ethanol in Rat Liver

Overview

Journal J Hepatol

Publisher Elsevier

Specialty Gastroenterology

Date 1988 Apr 1

PMID 3411096

Citations 22

Authors

A Benedetti

E Brunelli

R Risicato

T Cilluffo

A M JEZEQUEL

F Orlandi

Affiliations

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Abstract

The livers of rats given ethanol for 5 weeks showed marked structural alterations of hepatocytes of acinar zone 3 including mitochondrial pleomorphism, increased smooth endoplasmic reticulum and deposition of small (less than 0.5 micron) lipid droplets. In addition, apoptotic bodies involving altered parenchymal cells were frequently observed, together with prominent mononuclear infiltrates adjacent to the terminal hepatic veins. It is suggested that 'age' of liver cells may play a role in the preferential perivenular localization of early ethanol-induced liver damage.

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