Individual Differences in the Associations Between Risk Factors for Alcohol Use Disorder and Alcohol Use-related Outcomes

Overview

Journal Psychol Addict Behav

Publisher American Psychological Association

Specialties Psychiatry
Psychology

Date 2021 Jun 10

PMID 34110841

Citations 1

Authors

Angela M Haeny

Ralitza Gueorguieva

Asti Jackson

Meghan E Morean

Suchitra Krishnan-Sarin

Kelly S DeMartini

Godfrey D Pearlson

Alan Anticevic

John H Krystal

Stephanie S OMalley

Affiliations

Soon will be listed here.

Abstract

Background: Family history of alcohol use disorder; AUD (FH +) and impulsivity-related traits are known risk factors for problem drinking that have been investigated in predominately White samples. This cross-sectional study examined whether these risk factors vary by sex in the overall, majority White sample and in a Black subsample.

Method: A model building regression procedure was used to investigate the combined effect of FH + and impulsivity-related traits on alcohol quantity, frequency, and problems by sex (overall sample: = 757, 50% female, 73% White, age = 33.74, = 11.60; Black subsample: = 138, 47% female, age = 33.60, = 9.87).

Results: No sex differences were found in the compounding effects of FH + and impulsivity-related traits on alcohol outcomes. Males reported more physical, social, and overall alcohol-related problems than females. FH + was positively associated with all alcohol-related consequences. Poor self-regulation was the only trait associated with all alcohol outcomes. : A three-way interaction suggested a negative association between inhibition and frequency of alcohol use among FH + males only. A two-way interaction also suggested impulse control was associated with more interpersonal alcohol-related problems among males only. Main effects were also found in the expected direction such that higher impulsivity and FH + were associated with poorer alcohol outcomes.

Conclusion: These findings suggest no sex differences in the overall sample in the interactive effects of established risk factors for AUD on alcohol outcomes, and that poor self-regulation may be key for personality-targeted alcohol prevention and intervention programs. Preliminary findings of sex differences in the Black subsample should be replicated. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Citing Articles

Serial mediating effects of childhood trauma and conduct behaviors on the impact of family history among patients with alcohol use disorder.

Han M, Kim S, Il Park C, Hwang S, Kim H, Kang J Sci Rep. 2024; 14(1):7196.

PMID: 38532019 PMC: 10966099. DOI: 10.1038/s41598-024-57861-x.

References

Long E, Lonn S, Sundquist J, Sundquist K, Kendler K . The role of parent and offspring sex on risk for externalizing psychopathology in offspring with parental alcohol use disorder: a national Swedish study. Soc Psychiatry Psychiatr Epidemiol. 2018; 53(12):1381-1389. PMC: 6252126. DOI: 10.1007/s00127-018-1563-5. View

DeVito E, Meda S, Jiantonio R, Potenza M, Krystal J, Pearlson G . Neural correlates of impulsivity in healthy males and females with family histories of alcoholism. Neuropsychopharmacology. 2013; 38(10):1854-63. PMC: 3746701. DOI: 10.1038/npp.2013.92. View

Turecki G, Meaney M . Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review. Biol Psychiatry. 2015; 79(2):87-96. PMC: 4466091. DOI: 10.1016/j.biopsych.2014.11.022. View

Stone A, Becker L, Huber A, Catalano R . Review of risk and protective factors of substance use and problem use in emerging adulthood. Addict Behav. 2012; 37(7):747-75. DOI: 10.1016/j.addbeh.2012.02.014. View

Mathew R, Wilson W, Blazer D, George L . Psychiatric disorders in adult children of alcoholics: data from the Epidemiologic Catchment Area project. Am J Psychiatry. 1993; 150(5):793-800. DOI: 10.1176/ajp.150.5.793. View

Dick D, Smith G, Olausson P, Mitchell S, Leeman R, OMalley S . Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addict Biol. 2010; 15(2):217-26. PMC: 2895996. DOI: 10.1111/j.1369-1600.2009.00190.x. View

Sharma L, Markon K, Clark L . Toward a theory of distinct types of "impulsive" behaviors: A meta-analysis of self-report and behavioral measures. Psychol Bull. 2013; 140(2):374-408. DOI: 10.1037/a0034418. View

Zucker R, Heitzeg M, Nigg J . Parsing the Undercontrol/Disinhibition Pathway to Substance Use Disorders: A Multilevel Developmental Problem. Child Dev Perspect. 2011; 5(4):248-255. PMC: 3221325. DOI: 10.1111/j.1750-8606.2011.00172.x. View

Yoon G, Westermeyer J, Kuskowski M, Nesheim L . Impact of the number of parents with alcohol use disorder on alcohol use disorder in offspring: a population-based study. J Clin Psychiatry. 2013; 74(8):795-801. DOI: 10.4088/JCP.13m08350. View

10.

Gee G, Hing A, Mohammed S, Tabor D, Williams D . Racism and the Life Course: Taking Time Seriously. Am J Public Health. 2019; 109(S1):S43-S47. PMC: 6356137. DOI: 10.2105/AJPH.2018.304766. View

11.

Berg J, Latzman R, Bliwise N, Lilienfeld S . Parsing the heterogeneity of impulsivity: A meta-analytic review of the behavioral implications of the UPPS for psychopathology. Psychol Assess. 2015; 27(4):1129-46. DOI: 10.1037/pas0000111. View

12.

Mellentin A, Brink M, Andersen L, Erlangsen A, Stenager E, Bjerregaard L . The risk of offspring developing substance use disorders when exposed to one versus two parent(s) with alcohol use disorder: A nationwide, register-based cohort study. J Psychiatr Res. 2016; 80:52-58. DOI: 10.1016/j.jpsychires.2016.06.001. View

13.

Rutledge P, Sher K . Heavy drinking from the freshman year into early young adulthood: the roles of stress, tension-reduction drinking motives, gender and personality. J Stud Alcohol. 2001; 62(4):457-66. DOI: 10.15288/jsa.2001.62.457. View

14.

Pedersen S, Molina B, Belendiuk K, Donovan J . Racial differences in the development of impulsivity and sensation seeking from childhood into adolescence and their relation to alcohol use. Alcohol Clin Exp Res. 2012; 36(10):1794-802. PMC: 3463755. DOI: 10.1111/j.1530-0277.2012.01797.x. View

15.

Otiniano Verissimo A, Gee G, Ford C, Iguchi M . Racial discrimination, gender discrimination, and substance abuse among Latina/os nationwide. Cultur Divers Ethnic Minor Psychol. 2014; 20(1):43-51. PMC: 4060885. DOI: 10.1037/a0034674. View

16.

Keyes K, Jager J, Mal-Sarkar T, Patrick M, Rutherford C, Hasin D . Is There a Recent Epidemic of Women's Drinking? A Critical Review of National Studies. Alcohol Clin Exp Res. 2019; 43(7):1344-1359. PMC: 6602861. DOI: 10.1111/acer.14082. View

17.

Zapolski T, Pedersen S, McCarthy D, Smith G . Less drinking, yet more problems: understanding African American drinking and related problems. Psychol Bull. 2013; 140(1):188-223. PMC: 3758406. DOI: 10.1037/a0032113. View

18.

Fox H, Bergquist K, Peihua G, Rajita S . Interactive effects of cumulative stress and impulsivity on alcohol consumption. Alcohol Clin Exp Res. 2010; 34(8):1376-85. PMC: 3676668. DOI: 10.1111/j.1530-0277.2010.01221.x. View

19.

Agabio R, Campesi I, Pisanu C, Gessa G, Franconi F . Sex differences in substance use disorders: focus on side effects. Addict Biol. 2016; 21(5):1030-42. DOI: 10.1111/adb.12395. View

20.

Grigsby T, Forster M, Unger J, Sussman S . Predictors of alcohol-related negative consequences in adolescents: A systematic review of the literature and implications for future research. J Adolesc. 2016; 48:18-35. PMC: 4779657. DOI: 10.1016/j.adolescence.2016.01.006. View