Coronary Heart Disease and COVID-19: A Meta-analysis

Overview

Journal Med Clin (Engl Ed)

Date 2021 Jun 10

PMID 34109276

Citations 4

Authors

Chendi Liang

Weijun Zhang

Shuzhen Li

Gang Qin

Affiliations

Soon will be listed here.

Abstract

Objective: Since the World Health Organization (WHO) announced coronavirus disease 2019 (COVID-19) had become a global pandemic on March 11, 2020, the number of infections has been increasing. The purpose of this meta-analysis was to investigate the prognosis of COVID-19 in patients with coronary heart disease.

Method: Pubmed, Embase, and Cochrane Library databases were searched to collect the literature concerning coronary heart disease and COVID-19. The retrieval time was from inception to Nov 20, 2020, using Stata version 14.0 for meta-analysis.

Results: A total of 22,148 patients from 40 studies were included. The meta-analysis revealed that coronary heart disease was associated with poor prognosis of COVID-19 (OR=3.42, 95%CI [2.83, 4.13], < 0.001). After subgroup analysis, coronary heart disease was found to be related to mortality (OR = 3.75, 95%CI [2.91, 4.82], < 0.001), severe/critical COVID-19 (OR = 3.23, 95%CI [2.19, 4.77], < 0.001), ICU admission (OR = 2.25, 95%CI [1.34, 3.79], = 0.002), disease progression (OR = 3.01, 95%CI [1.46, 6.22], = 0.003); Meta-regression showed that the association between coronary heart disease and poor prognosis of COVID-19 was affected by hypertension ( = 0.004), and subgroup analysis showed that compared with the proportion of hypertension >30% (OR = 2.85, 95%CI [2.33, 3.49]), the proportion of hypertension <30% (OR = 4.78, 95%CI [3.50, 6.51]) had a higher risk of poor prognosis.

Conclusion: Coronary heart disease is a risk factor for poor prognosis in patients with COVID-19.

Citing Articles

The effect of integrated medical care on the daily life of patients with coronary heart disease.

Xiao H, Deng Y, Xiao H, Liu X, Qin N Medicine (Baltimore). 2024; 103(49):e40587.

PMID: 39654252 PMC: 11631026. DOI: 10.1097/MD.0000000000040587.

Collette T, Stevens L, Robinson-Dooley V, Sterling E Soc Work Public Health. 2024; 39(7):734-749.

PMID: 39068542 PMC: 11408096. DOI: 10.1080/19371918.2024.2381621.

Excess deaths directly and indirectly attributable to COVID-19 using routinely reported mortality data, Bishkek, Kyrgyzstan, 2020: a cross-sectional study.

Bumburidi Y, Dzhalimbekova A, Malisheva M, Moolenaar R, Horth R, Singer D BMJ Open. 2023; 13(7):e069521.

PMID: 37433726 PMC: 10347454. DOI: 10.1136/bmjopen-2022-069521.

Autoimmune Reaction Associated With Long COVID Syndrome and Cardiovascular Disease: A Genetic Case Report.

Safronenka A, Capcha J, Webster K, Buglo E, Tamariz L, Goldberger J JACC Case Rep. 2022; 6:101644.

PMID: 36348978 PMC: 9633038. DOI: 10.1016/j.jaccas.2022.09.014.

References

Shi S, Qin M, Cai Y, Liu T, Shen B, Yang F . Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019. Eur Heart J. 2020; 41(22):2070-2079. PMC: 7239100. DOI: 10.1093/eurheartj/ehaa408. View

Sun L, Song F, Shi N, Liu F, Li S, Li P . Combination of four clinical indicators predicts the severe/critical symptom of patients infected COVID-19. J Clin Virol. 2020; 128:104431. PMC: 7219384. DOI: 10.1016/j.jcv.2020.104431. View

Chen Y, Ke Y, Liu X, Wang Z, Jia R, Liu W . Clinical features and antibody response of patients from a COVID-19 treatment hospital in Wuhan, China. J Med Virol. 2020; 93(5):2782-2789. DOI: 10.1002/jmv.26617. View

Cen Y, Chen X, Shen Y, Zhang X, Lei Y, Xu C . Risk factors for disease progression in patients with mild to moderate coronavirus disease 2019-a multi-centre observational study. Clin Microbiol Infect. 2020; 26(9):1242-1247. PMC: 7280135. DOI: 10.1016/j.cmi.2020.05.041. View

Barman H, Atici A, Sahin I, Alici G, Tekin E, Baycan O . Prognostic significance of cardiac injury in COVID-19 patients with and without coronary artery disease. Coron Artery Dis. 2020; 32(5):359-366. PMC: 7365584. DOI: 10.1097/MCA.0000000000000914. View

Liu Y, Li G, He J, Liu Y, Li M, Zhang R . Combined use of the neutrophil-to-lymphocyte ratio and CRP to predict 7-day disease severity in 84 hospitalized patients with COVID-19 pneumonia: a retrospective cohort study. Ann Transl Med. 2020; 8(10):635. PMC: 7290615. DOI: 10.21037/atm-20-2372. View

Iaccarino G, Grassi G, Borghi C, Ferri C, Salvetti M, Volpe M . Age and Multimorbidity Predict Death Among COVID-19 Patients: Results of the SARS-RAS Study of the Italian Society of Hypertension. Hypertension. 2020; 76(2):366-372. DOI: 10.1161/HYPERTENSIONAHA.120.15324. View

Islam M, Riaz B, Islam A, Khanam F, Akhter J, Choudhury R . Risk factors associated with morbidity and mortality outcomes of COVID-19 patients on the 28th day of the disease course: a retrospective cohort study in Bangladesh. Epidemiol Infect. 2020; 148:e263. PMC: 7653486. DOI: 10.1017/S0950268820002630. View

Maeda T, Obata R, Rizk DO D, Kuno T . The association of interleukin-6 value, interleukin inhibitors, and outcomes of patients with COVID-19 in New York City. J Med Virol. 2020; 93(1):463-471. DOI: 10.1002/jmv.26365. View

10.

Wang C, Hu S, Wang L, Li M, Li H . Early risk factors of the exacerbation of coronavirus disease 2019 pneumonia. J Med Virol. 2020; 92(11):2593-2599. PMC: 7283729. DOI: 10.1002/jmv.26071. View

11.

Lendorf M, Boisen M, Kristensen P, Lokkegaard E, Krog S, Brandi L . Characteristics and early outcomes of patients hospitalised for COVID-19 in North Zealand, Denmark. Dan Med J. 2020; 67(9). View

12.

Gross S, Jahn C, Cushman S, Bar C, Thum T . SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications. J Mol Cell Cardiol. 2020; 144:47-53. PMC: 7191280. DOI: 10.1016/j.yjmcc.2020.04.031. View

13.

Chen L, Li X, Chen M, Feng Y, Xiong C . The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020; 116(6):1097-1100. PMC: 7184507. DOI: 10.1093/cvr/cvaa078. View

14.

Xiong T, Redwood S, Prendergast B, Chen M . Coronaviruses and the cardiovascular system: acute and long-term implications. Eur Heart J. 2020; 41(19):1798-1800. PMC: 7454513. DOI: 10.1093/eurheartj/ehaa231. View

15.

Wang K, Zuo P, Liu Y, Zhang M, Zhao X, Xie S . Clinical and Laboratory Predictors of In-hospital Mortality in Patients With Coronavirus Disease-2019: A Cohort Study in Wuhan, China. Clin Infect Dis. 2020; 71(16):2079-2088. PMC: 7197616. DOI: 10.1093/cid/ciaa538. View

16.

Deng P, Ke Z, Ying B, Qiao B, Yuan L . The diagnostic and prognostic role of myocardial injury biomarkers in hospitalized patients with COVID-19. Clin Chim Acta. 2020; 510:186-190. PMC: 7363604. DOI: 10.1016/j.cca.2020.07.018. View

17.

Stang A . Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010; 25(9):603-5. DOI: 10.1007/s10654-010-9491-z. View

18.

Russo V, Di Maio M, Attena E, Silverio A, Scudiero F, Celentani D . Clinical impact of pre-admission antithrombotic therapy in hospitalized patients with COVID-19: A multicenter observational study. Pharmacol Res. 2020; 159:104965. PMC: 7256617. DOI: 10.1016/j.phrs.2020.104965. View

19.

Cipriani A, Capone F, Donato F, Molinari L, Ceccato D, Saller A . Cardiac injury and mortality in patients with Coronavirus disease 2019 (COVID-19): insights from a mediation analysis. Intern Emerg Med. 2020; 16(2):419-427. PMC: 7520162. DOI: 10.1007/s11739-020-02495-w. View

20.

Jackson B, Gold J, Natarajan P, Rossow J, Fanfair R, da Silva J . Predictors at Admission of Mechanical Ventilation and Death in an Observational Cohort of Adults Hospitalized With Coronavirus Disease 2019. Clin Infect Dis. 2020; 73(11):e4141-e4151. PMC: 7543323. DOI: 10.1093/cid/ciaa1459. View