Intratumoral Synthesis of Nano-metalchelate for Tumor Catalytic Therapy by Ligand Field-enhanced Coordination

Overview

Journal Nat Commun

Specialty Biology

Date 2021 Jun 8

PMID 34099712

Citations 19

Authors

Bowen Yang

Heliang Yao

Han Tian

Zhiguo Yu

Yuedong Guo

Yuemei Wang

Jiacai Yang

Chang Chen

Jianlin Shi

Affiliations

Soon will be listed here.

Abstract

The iron gall ink-triggered chemical corrosion of hand-written documents is a big threat to Western cultural heritages, which was demonstrated to result from the iron gall (GA-Fe) chelate-promoted reactive oxygen species generation. Such a phenomenon has inspired us to apply the pro-oxidative mechanism of GA-Fe to anticancer therapy. In this work, we construct a composite cancer nanomedicine by loading gallate into a Fe-engineered mesoporous silica nanocarrier, which can degrade in acidic tumor to release the doped Fe and the loaded gallate, forming GA-Fe nanocomplex in situ. The nanocomplex with a highly reductive ligand field can promote oxygen reduction reactions generating hydrogen peroxide. Moreover, the resultant two-electron oxidation form of GA-Fe is an excellent Fenton-like agent that can catalyze hydrogen peroxide decomposition into hydroxyl radical, finally triggering severe oxidative damage to tumors. Such a therapeutic approach by intratumoral synthesis of GA-Fe nano-metalchelate may be instructive to future anticancer researches.

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